Evidence map›Paper›PMID 38801124›Full record

ReviewAlzheimer's & dementia : the journal of the Alzheimer's Association2024

Advancements in dementia research, diagnostics, and care in Latin America: Highlights from the 2023 Alzheimer's Association International conference satellite symposium in Mexico City.

Ana Luisa Sosa, Sonia Md Brucki, Lucia Crivelli, Francisco Javier Lopera, Daisy M Acosta, Juliana Acosta-Uribe, Diego Aguilar, Sara G Aguilar-Navarro, Ricardo F Allegri, Paulo Hf Bertolucci and 34 more

Abstract readReview
In one paragraph

Review in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Bibliometric analysis of Alzheimer's and dementia research in Latin America.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Lewy Body Dementia Research in Latin America: A Scoping Review.Movement disorders clinical practice · 2025
    Article
  12. Review
  13. Article
  14. Need to adapt Alzheimer's disease criteria in Latin America.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

44 authors.

Ana Luisa SosaLaboratorio de Demencias del Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City, CDMX, México.
Sonia Md BruckiDepartment of Neurology, Cognitive and Behavioral Group, University of Sao Paulo, São Paulo, São Paulo, Brazil.
Lucia CrivelliDepartment of Cognitive Neurology, Fleni, Buenos Aires, Argentina.
Francisco Javier LoperaGrupo de Neurociencias (GNA), Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.
Daisy M AcostaUniversidad Nacional Pedro Henriquez Urena (UNPHU), Santo Domingo, Dominican Republic.
Juliana Acosta-UribeGrupo de Neurociencias (GNA), Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.
Diego AguilarAlzheimer's Disease International, London, UK.
Sara G Aguilar-NavarroDepartment of Geriatrics, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubiran, México, CDMX, Mexico.
Ricardo F AllegriInstituto de Neurociencias, Fleni, Buenos Aires, Argentina.
Paulo Hf BertolucciNeurology & Neurosurgery Department, Escola Paulista de Medicina/UNIFESP, São Paulo, São Paulo, Brazil.
Ismael L CalandriDepartment of Cognitive Neurology, Fleni, Buenos Aires, Argentina.
Maria C CarrilloAlzheimer's Association, Chicago, Illinois, USA.
Patricio Alexis Chrem MendezMemory Center, Fleni, Buenos Aires, Argentina.
Mario Cornejo-OlivasNeurogenetics Working Group, Universidad Científica del Sur, Lima, Peru.
Nilton CustodioUnidad de Diagnóstico de Deterioro Cognitivo y Prevención de Demencia, Instituto Peruano de Neurociencias, Lima, Peru.
Andrés DamianDepartamento de Montevideo, Centro Uruguayo de Imagenología Molecular (CUDIM) and Unidad Académica de Medicina Nuclear e Imagenología Molecular, Hospital de Clínicas, Universidad de la República (UdelaR), Montevideo, Montevideo, Uruguay.
Leonardo Cruz de SouzaPrograma de Pós-Graduação em Neurociências, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.
Claudia Duran-AniotzLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Santiago, Chile.
Adolfo M GarcíaLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Santiago, Chile.
Carmen García-PeñaInstituto Nacional de Geriatría, México, CDMX, Mexico.
Mitzi M GonzalesDepartment of Neurology, Cedars Sinai Medical Center, Los Angeles, California, USA.
Lea T GrinbergDepartment of Neurology and Pathology, University of California San Francisco (UCSF), San Francisco, California, USA.
Agustin M IbanezLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Santiago, Chile.
Maryenela Zaida Illanes-ManriqueNeurogenetics Working Group, Universidad Científica del Sur, Lima, Peru.
Clifford R JackMayo Clinic, Rochester, Minnesota, USA.
Jorge Mario Leon-SalasDepartamento de Investigación Clínica, Life Science Research Institute, Hospital Clinica Biblica, San José, Costa Rica.
Jorge J Llibre-GuerraDominantly Inherited Alzheimer's Network Trials Unit, Washington University School of Medicine, St. Louis, Missouri, USA.
José Luna-MuñozBanco Nacional de Cerebros-UNPHU, Universidad Nacional Pedro Henríquez Ureña, Santo Domingo, Dominican Republic.
Diana MatallanaPontificia Universidad Javeriana, Medical School, Aging Institute, Hospital Universitario San Ignacio, Bogotá, Colombia.
Bruce L MillerGlobal Brain Health Institute (GBHI), University of California San Francisco (UCSF), San Francisco, California, USA.
Lorina NaciGlobal Brain Health Institute (GBHI), University of Trinity Dublin, Lloyd Building Trinity College Dublin, Dublin, Ireland.
Mario A ParraDepartment of Psychological Sciences and Health, University of Strathclyde, Glasgow, UK.
Margaret Pericak-VanceJohn P Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Coral Gables, Florida, USA.
Stefanie D Piña-EscuderoGlobal Brain Health Institute (GBHI), University of California San Francisco (UCSF), San Francisco, California, USA.
Elisa de Paula França ResendeGlobal Brain Health Institute (GBHI), University of California San Francisco (UCSF), San Francisco, California, USA.
John M RingmanDepartment of Neurology, Alzheimer's Disease Research Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Gustavo SevleverDepartment of Neuropathology, Fleni, Buenos Aires, Argentina.
Andrea SlachevskyGeroscience Center for Brain Health and Metabolism (GERO), Santiago, Chile.
Claudia Kimie SuemotoDivision of Geriatrics, University of Sao Paulo Medical School, São Paulo, São Paulo, Brazil.
Victor ValcourDepartment of Neurology, University of California San Francisco (UCSF), San Francisco, California, USA.
Andres Villegas-LanauGrupo de Neurociencias (GNA), Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.
Mônica S YassudaDepartment of Neurology, Cognitive and Behavioral Group, University of Sao Paulo, São Paulo, São Paulo, Brazil.
Simin MahinradAlzheimer's Association, Chicago, Illinois, USA.ORCID 0000-0002-5927-7130
Claire SextonAlzheimer's Association, Chicago, Illinois, USA.ORCID 0000-0002-3846-2986

Funding

TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2M
The Neighborhoods Study: Contextual Disadvantage and Alzheimer’s Disease and Related Dementias (ADRD)R01AG070883 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI AMY J. KIND · 2021 to 2026
$42.1M
Research Education ComponentP30AG062422 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Katherine P Rankin · 2019 to 2026
$36.9M
USCADRC Diversity Supplement PachicanoP30AG066530 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HELENA Chang CHUI · 2020 to 2026
$27.8M
An automated machine learning approach to language changes in Alzheimer’s disease and frontotemporal dementia across Latino and English-speaking populationsR01AG075775 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARIA LUISA GORNO TEMPINI, Adolfo Martin Garcia · 2023 to 2026
$7.2M
Emotion network dysfunction and decline in early frontotemporal dementiaR01AG052496 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Virginia Emily Sturm · 2017 to 2026
$6.9M
US-South American Initiative for Genetic-Neural-Behavioral Interactions in Human Neurodegenerative ResearchR01AG057234 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Claudia Duran-Aniotz, Agustin M. Ibanez · 2019 to 2026
$6.1M
Tracking longitudinal change in presymptomatic genetic prion disease (TLC-Pre-gPrD)R01AG062562 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GESCHWIND, MICHAEL D · 2019 to 2023
$5.4M
Reimagining Precision Medicine Approaches to AD DiagnosisR35AG072362 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI POSSIN, KATHERINE LAUREL, RABINOVICI, GIL DAN · 2021 to 2025
$4.8M
Imaging Cerebral and Retinal Microvasculature in Cerebral Small Vessel DiseaseUH3NS100614 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KASHANI, AMIR H, WANG, DANNY JJ · 2018 to 2020
$4.3M
Motor, Visual, and Olfactory Changes in Genetic Subtypes of Alzheimer’s DiseaseR01AG062007 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI RINGMAN, JOHN M · 2019 to 2023
$4.1M
Elucidating clinical heterogeneity in early-onset AD via genomics, transcriptomics, and neuroimagingR01AG062588 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI YOKOYAMA, JENNIFER S · 2019 to 2023
$4.0M
Alzheimer's AssociationLatAm FINGERSNIA NIH HHS K01 AG073526NIA NIH HHS P01 AG019724NIA NIH HHS P30 AG062422NIA NIH HHS P30 AG066530NIA NIH HHS R01 AG052496NIA NIH HHS R01 AG057234NIA NIH HHS R01 AG062007NIA NIH HHS R01 AG062562NIA NIH HHS R01 AG062588NIA NIH HHS R01 AG064778NIA NIH HHS R01 AG070883NIA NIH HHS R01 AG075775NIA NIH HHS R35 AG072362NIA NIH HHS R56 AG069118NIA NIH HHS SG-20-725707NIHNINDS NIH HHS R01 NS114382NINDS NIH HHS UH3 NS100614Rainwater Charitable Foundation and Center for Alzheimer's Disease and Related DementiasRainwater Charitable Foundation - Tau Consortium, and Global Brain Health Institutethe Alzheimer's Association and FAPESPthe Brazilian National Council for Scientific and Technological Development (CNPq) 308606/2022-1
6 · The paper itself

Abstract

introductionWhile Latin America (LatAm) is facing an increasing burden of dementia due to the rapid aging of the population, it remains underrepresented in dementia research, diagnostics, and care.

methodsIn 2023, the Alzheimer's Association hosted its eighth satellite symposium in Mexico, highlighting emerging dementia research, priorities, and challenges within LatAm.

resultsSignificant initiatives in the region, including intracountry support, showcased their efforts in fostering national and international collaborations; genetic studies unveiled the unique genetic admixture in LatAm; researchers conducting emerging clinical trials discussed ongoing culturally specific interventions; and the urgent need to harmonize practices and studies, improve diagnosis and care, and use affordable biomarkers in the region was highlighted. DISCUSSION: The myriad of topics discussed at the 2023 AAIC satellite symposium highlighted the growing research efforts in LatAm, providing valuable insights into dementia biology, genetics, epidemiology, treatment, and care.

Indexed as

DementiaAlzheimer DiseaseBiomedical ResearchCongresses as TopicHumansLatin AmericaMexicoAlzheimer's diseasebiomarkersdementiageneticsHispanicsLatin America

Identifiers

PMID38801124
PMCPMC11247679

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.