Evidence map›Paper›PMID 38800892›Full record

Trial reportMaternal & child nutrition2024

Effect of a simplified approach on recovery of children 6-59 months with wasting in Ethiopia: A noninferiority, cluster randomized controlled trial.

Yetayesh Maru, Dessalegn Tamiru, Kaleab Baye, Stanley Chitekwe, Arnaud Laillou, Hiwot Darsene, Rashid Abdulai, Mesfin Worku, Tefera Belachew

Registry-linked trialAbstract readRandomized Controlled TrialEquivalence Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Maternal & child nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06792370 (Effectiveness of an Alternative Protocol in the Management of Acute Malnutrition in Children Aged 6-59 Months in Burkina Faso), which is not on this map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06792370 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Effectiveness of an Alternative Protocol in the Management of Acute Malnutrition in Children Aged 6-59 Months in Burkina Faso: Reduced Dose of RUTF for SAM Children and RUTF Instead of RUSF for MAM Children

TypeinterventionalSponsorInstitut de Recherche en Sciences de la Sante, Burkina FasoRan2025 to 2026Enrolled3,521ConditionsAcute Malnutrition with No ComplicationsArmsready-to-use therapeutic food (for children with MAM), Ready-to-use supplementary food, Ready to Use Therapeutic Food - Reduced dose 1, Ready to Use Therapeutic Food - Standard dose, Ready to Use Therapeutic Food - Reduced dose 2
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yetayesh MaruNutrition and Dietetics Department, Faculty of Public Health, Jimma University, Jimma, Ethiopia.ORCID 0009-0004-9899-2139
Dessalegn TamiruNutrition and Dietetics Department, Faculty of Public Health, Jimma University, Jimma, Ethiopia.
Kaleab BayeCenter for Food Science and Nutrition, Addis Ababa University, Addis Ababa, Ethiopia.
Stanley ChitekweNutrition Section, UNICEF Ethiopia, Addis Ababa, Ethiopia.ORCID 0000-0003-0915-333X
Arnaud LaillouUNICEF West and Central Africa Regional Office, Nutrition Section, Dakar, Senegal.ORCID 0000-0002-2315-223X
Hiwot DarseneNutrition Coordination Office, Ethiopian Ministry of Health, Addis Ababa, Ethiopia.
Rashid AbdulaiNutrition Section, UNICEF Ethiopia, Addis Ababa, Ethiopia.
Mesfin WorkuNutrition Section, UNICEF Ethiopia, Addis Ababa, Ethiopia.
Tefera BelachewNutrition and Dietetics Department, Faculty of Public Health, Jimma University, Jimma, Ethiopia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Worldwide, nearly 45 million children under the age of 5 years were affected by wasting in 2022. Ethiopia has been challenged by disasters increasing the caseload of children with wasting. This study aimed to determine the effect of a simplified approach on recovery of children with acute malnutrition as compared with the standard protocol. A cluster randomized, controlled, noninferiority trial was carried out in three regions of Ethiopia from December 4, 2021, to July 30, 2022. A total of 58 clusters (health posts) were randomized into intervention and control groups. Children with SAM in the intervention groups received two sachets of Ready-to-Use Therapeutic Food (RUTF), whereas children in the control groups received RUTF based on their body weight. Children with moderate acute malnutrition (MAM) received one sachet of RUTF and one sachet of Ready-to-Use Supplementary Food (RUSF) daily in the intervention and control groups, respectively. Per protocol (PP) and intention-to-treat analysis were used to compare recovery at a noninferiority margin of 15%. Data were collected from 55 health posts and 1032 children. In the PP analysis, the recovery rate of children with wasting among the simplified group (97.8%) was noninferior to the standard protocol group (97.7%), p = 0.399. The RUTF cost per treatment of child with SAM was 56.55 USD for the standard versus 42.78 USD for the simplified approach. The simplified approach is noninferior to the standard protocol in terms of recovery and has a lower cost of RUTF. Further study is recommended to assess the effectiveness of the simplified approach in emergency contexts.

Indexed as

Wasting SyndromeChild, PreschoolCluster AnalysisEthiopiaFast FoodsFemaleHumansInfantMalecluster randomizedcostmoderate acute malnutritionmodified dosagenoninferioritysevere acute malnutritionwasting

Identifiers

PMID38800892
PMCPMC11574638

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.