Evidence map›Paper›PMID 38800833›Full record

ArticleFrontiers in cellular and infection microbiology2024

HSP90 is part of a protein complex with the L polymerase of Rift Valley fever phlebovirus and prevents its degradation by the proteasome during the viral genome replication/transcription stage.

Farhang Alem, Ashwini Brahms, Kaori Tarasaki, Samson Omole, Kylene Kehn-Hall, Connie S Schmaljohn, Sina Bavari, Shinji Makino, Ramin M Hakami

Abstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Farhang AlemSchool of Systems Biology, George Mason University, Manassas, VA, United States.
Ashwini BrahmsSchool of Systems Biology, George Mason University, Manassas, VA, United States.
Kaori TarasakiDepartment of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, TX, United States.
Samson OmoleSchool of Systems Biology, George Mason University, Manassas, VA, United States.
Kylene Kehn-HallSchool of Systems Biology, George Mason University, Manassas, VA, United States.
Connie S SchmaljohnIntegrated Research Facility at Fort Detrick, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, Frederick, MD, United States.
Sina BavariTonix Pharmaceuticals, Frederick, MD, United States.
Shinji MakinoDepartment of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, TX, United States.
Ramin M HakamiSchool of Systems Biology, George Mason University, Manassas, VA, United States.

Funding

Infection Site Targeted Antitoxin Antibody (ISTAb) against Bacillus anthracisR41AI122666 · NIAID · INTEGRATED BIOTHERAPEUTICS, INC. · PI ADHIKARI, RAJAN P, HAKAMI, RAMIN M. · 2017 to 2018
$595k
Mechanism of viral RNP recognition by the envelope glycoprotein and its role in RNA segment packaging in Rift Valley Fever phlebovirusR21AI148763 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI MAKINO, SHINJI · 2020 to 2021
$435k
Rational Development of a Novel Attenuated Rift Valley Fever Virus VaccineR21AI127984 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI MAKINO, SHINJI · 2017 to 2018
$426k
NIAID NIH HHS R21 AI127984NIAID NIH HHS R21 AI148763NIAID NIH HHS R41 AI122666
6 · The paper itself

Abstract

The mosquito-borne Rift Valley fever virus (RVFV) from the

Indexed as

HSP90 Heat-Shock ProteinsProteasome Endopeptidase ComplexProteolysisRift Valley fever virusVirus ReplicationAnimalsCell LineGenome, ViralHost-Pathogen InteractionsHumansRift Valley FeverRNA-Dependent RNA PolymeraseTranscription, GeneticViral ProteinsHSP90 Heat-Shock ProteinsProteasome Endopeptidase ComplexRNA-Dependent RNA PolymeraseViral Proteinsheat shock proteinHsp90L proteinproteasomeprotein degradationprotein stabilityRift Valley fever virusRNA-dependent RNA polymerase

Identifiers

PMID38800833
PMCPMC11127626

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.