Evidence map›Paper›PMID 38800659›Full record

ArticleArXiv2024

Identifying the minimal sets of distance restraints for FRET-assisted protein structural modeling.

Zhuoyi Liu, Alex T Grigas, Jacob Sumner, Edward Knab, Caitlin M Davis, Corey S O'Hern

Abstract readPreprint
PubMed Full text at PMC
In one paragraph

Article in ArXiv, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Zhuoyi LiuDepartment of Mechanical Engineering and Materials Science, Yale University, New Haven, Connecticut, 06520, USA.
Alex T GrigasIntegrated Graduate Program in Physical and Engineering Biology, Yale University, New Haven, Connecticut, 06520, USA.
Jacob SumnerIntegrated Graduate Program in Physical and Engineering Biology, Yale University, New Haven, Connecticut, 06520, USA.
Edward KnabDepartment of Chemistry, Yale University, New Haven, Connecticut, 06520, USA.
Caitlin M DavisDepartment of Chemistry, Yale University, New Haven, Connecticut, 06520, USA.
Corey S O'HernDepartment of Mechanical Engineering and Materials Science, Yale University, New Haven, Connecticut, 06520, USA.

Funding

MEDICAL INFORMATICS RESEARCH TRAINING AT YALET15LM007056 · NLM · YALE UNIVERSITY · PI Mark Bender Gerstein, LUCILA OHNO-MACHADO · 1987 to 2026
$22.2M
Protein Structural Dynamics in Living CellsR35GM151146 · NIGMS · YALE UNIVERSITY · PI Caitlin Davis · 2023 to 2026
$1.7M
Convergent graduate training in systems biology at YaleT32GM145452 · NIGMS · YALE UNIVERSITY · PI KATHRYN MILLER-JENSEN, Corey O'Hern · 2022 to 2026
$1.0M
NIGMS NIH HHS R35 GM151146NIGMS NIH HHS T32 GM145452NLM NIH HHS T15 LM007056
6 · The paper itself

Abstract

Proteins naturally occur in crowded cellular environments and interact with other proteins, nucleic acids, and organelles. Since most previous experimental protein structure determination techniques require that proteins occur in idealized, non-physiological environments, the effects of realistic cellular environments on protein structure are largely unexplored. Recently, Förster resonance energy transfer (FRET) has been shown to be an effective experimental method for investigating protein structure

Indexed as

cellular crowdingFRET experimentsin vivo protein structuremolecular dynamics simulations

Identifiers

PMID38800659
PMCPMC11118665

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.