Evidence map›Paper›PMID 38800581›Full record

ArticleInfection and drug resistance2024

N-Butylphthalide Potentiates the Effect of Fluconazole Against Drug-Resistant

Yixin Liu, Feifei Ren, Shan Li, Xiangchen Li, Dongyan Shi, Zhiqing Zhang

Abstract read
In one paragraph

Article in Infection and drug resistance, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yixin LiuDepartment of Pharmacy, the Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, People's Republic of China.ORCID 0000-0002-1718-7284
Feifei RenDepartment of Pharmacy, the Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, People's Republic of China.
Shan LiDepartment of Pharmacy, the Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, People's Republic of China.
Xiangchen LiDepartment of Pharmacy, the Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, People's Republic of China.
Dongyan ShiDepartment of Clinical Laboratory, the Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, People's Republic of China.
Zhiqing ZhangDepartment of Pharmacy, the Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To define the antifungal activity of n-butylphthalide alone or in combination with fluconazole in Methods: The antifungal activity of n-butylphthalide alone and in combination with fluconazole was investigated by the classical broth microdilution method and the time-killing curve method. The QRT-PCR method was used to determine gene expressions changes of mitochondrial respiratory chain enzymes, drug efflux pumps and drug target enzymes in Results: The MIC values of n-butylphthalide against Conclusion: N-butylphthalide had antifungal activity against

Indexed as

Candida glabrataCandida tropicalisdrug resistancefluconazolen-butylphthalidepotentiation

Identifiers

PMID38800581
PMCPMC11127662

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.