ArticleFrontiers in endocrinology2024
The L-shape relationship between hemoglobin, albumin, lymphocyte, platelet score and the risk of diabetic retinopathy in the US population.
Article in Frontiers in endocrinology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Association of the Hemoglobin-Albumin-Lymphocyte-Platelet (HALP) Score with Diabetic Retinopathy Severity: A Case-Control Comparison with Non-Diabetic Ophthalmology Patients.Journal of clinical medicine · 2026Article
- The Association Between the HALP Score and Glycemic Control in Older Adults with Type 2 Diabetes Mellitus Receiving Home Health Care.Healthcare (Basel, Switzerland) · 2026Article
- Causal association between circulating leukocyte characteristics and diabetic retinopathy based on two-sample Mendelian randomization.Journal of diabetes investigation · 2026Article
- A novel nomogram based on HALP score for predicting time to glycemic stability in hospitalized type 2 diabetes patients.Frontiers in endocrinology · 2026Article
- Association of hemoglobin, albumin, lymphocyte, and platelet score with all-cause and cardiovascular mortality in adults with diabetes or prediabetes: Results from NHANES 2005-2018.Preventive medicine reports · 2025Article
- Association between Hemoglobin-albumin-lymphocyte-platelet score and all-cause or cardiovascular mortality in patients with diabetes or prediabetes: mediated effects of renal function.BMC cardiovascular disorders · 2025Article
- The relationship between hemoglobin, albumin, lymphocyte, and platelet (HALP) score and 28-day mortality in patients with sepsis: a retrospective analysis of the MIMIC-IV database.BMC infectious diseases · 2025Article
- Association of inflammation and nutrition-based indicators and diabetic foot ulcers: a cross-sectional study and a retrospective study.Frontiers in endocrinology · 2025Article
- The association of HALP score with low muscle mass in older adults.Frontiers in nutrition · 2025Article
- Association of the hemoglobin, albumin, lymphocyte, and platelet score with the risk of Erectile dysfunction: a cross-sectional study.Scientific reports · 2024Article
- Does First Blood Draw Matter in Retinopathy of Prematurity: A Comparative Analysis of Inflammation and Hypoxia-Related Parameters.Romanian journal of ophthalmologyArticle
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Authors and funding
7 authors.
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Abstract
Background: The primary aim of this study was to investigate the correlation between diabetic retinopathy (DR) and the HALP score (hemoglobin, albumin, lymphocyte, and platelet) in individuals with diabetes within the United States population. Methods: This cross-sectional investigation was based on the National Health and Nutrition Examination Survey (NHANES) database from 2003-2018. The following module calculated the HALP score: HALP score = [lymphocytes (/L) × hemoglobin (g/L) × albumin (g/L)]/platelets (/L). By performing the receiver operating characteristic (ROC) analysis, the optimal cutoff value of HALP was ascertained. Restricted cubic splines (RCS), multivariable logistic regression analysis, sensitivity analysis, and subgroup analysis were conducted to evaluate the effect of the HALP score on DR patients. Finally, the decision curve analysis (DCA) and clinical impact curve (CIC) were conducted to estimate the predictive power and clinical utility of the HALP score with clinical indicators. Results: According to the cutoff value (42.9) determined by the ROC curve, the participants were stratified into a lower HALP group (HALP Conclusion: The HALP score has an L-shaped correlation with the risk of DR, and thus, the HALP score may contribute to the timely intervention of diabetes patients.
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