Evidence map›Paper›PMID 38800486›Full record

ArticleFrontiers in endocrinology2024

The effect of epigenetic aging on neurodegenerative diseases: a Mendelian randomization study.

Jingqi Fan, Qing Liu, Xin Liu, Mengjiao Gong, Ian I Leong, YauKeung Tsang, Xiaoyan Xu, Suying Lei, Lining Duan, Yifan Zhang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jingqi FanInstitute of Neurology, Guangzhou University of Chinese Medicine, Guangzhou, China.
Qing LiuInstitute of Neurology, Guangzhou University of Chinese Medicine, Guangzhou, China.
Xin LiuInstitute of Neurology, Guangzhou University of Chinese Medicine, Guangzhou, China.
Mengjiao GongInstitute of Neurology, Guangzhou University of Chinese Medicine, Guangzhou, China.
Ian I LeongInstitute of Neurology, Guangzhou University of Chinese Medicine, Guangzhou, China.
YauKeung TsangInstitute of Neurology, Guangzhou University of Chinese Medicine, Guangzhou, China.
Xiaoyan XuInstitute of Neurology, Guangzhou University of Chinese Medicine, Guangzhou, China.
Suying LeiInstitute of Neurology, Guangzhou University of Chinese Medicine, Guangzhou, China.
Lining DuanInstitute of Neurology, Guangzhou University of Chinese Medicine, Guangzhou, China.
Yifan ZhangInstitute of Neurology, Guangzhou University of Chinese Medicine, Guangzhou, China.
Muxi LiaoThe First Affiliated Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China.
Lixing ZhuangThe First Affiliated Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Aging has always been considered as a risk factor for neurodegenerative diseases, but there are individual differences and its mechanism is not yet clear. Epigenetics may unveil the relationship between aging and neurodegenerative diseases. Methods: Our study employed a bidirectional two-sample Mendelian randomization (MR) design to assess the potential causal association between epigenetic aging and neurodegenerative diseases. We utilized publicly available summary datasets from several genome-wide association studies (GWAS). Our investigation focused on multiple measures of epigenetic age as potential exposures and outcomes, while the occurrence of neurodegenerative diseases served as potential exposures and outcomes. Sensitivity analyses confirmed the accuracy of the results. Results: The results show a significant decrease in risk of Parkinson's disease with GrimAge (OR = 0.8862, 95% CI 0.7914-0.9924, Conclusion: The findings firstly provide evidence for causal association of epigenetic aging and neurodegenerative diseases. Exploring neurodegenerative diseases from an epigenetic perspective may contribute to diagnosis, prognosis, and treatment of neurodegenerative diseases.

Indexed as

AgingEpigenesis, GeneticGenome-Wide Association StudyMendelian Randomization AnalysisNeurodegenerative DiseasesAlzheimer DiseaseGenetic Predisposition to DiseaseHumansParkinson DiseasePlasminogen Activator Inhibitor 1Risk FactorsPlasminogen Activator Inhibitor 1Alzheimer’s diseaseepigenetic agingMendelian randomization studyMultiple Sclerosisneurodegenerative diseasesParkinson’s disease

Identifiers

PMID38800486
PMCPMC11116635

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.