ArticleNetwork neuroscience (Cambridge, Mass.)2022
Effects of classic psychedelic drugs on turbulent signatures in brain dynamics.
Article in Network neuroscience (Cambridge, Mass.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Synergistic, multi-level understanding of psychedelics: three systematic reviews and meta-analyses of their pharmacology, neuroimaging and phenomenology.Translational psychiatry · 2024Pooled it
- Turbulent-like Dynamics Predict Treatment Outcome in Major Depressive Disorder.Research square · 2025Article
- Perturbing whole-brain models of brain hierarchy: An application for depression following pharmacological treatment.Annals of the New York Academy of Sciences · 2025Article
- Whole-brain turbulent dynamics predict responsiveness to pharmacological treatment in major depressive disorder.Molecular psychiatry · 2025Article
- A Dynamic Entropy Approach Reveals Reduced Functional Network Connectivity Trajectory Complexity in Schizophrenia.Entropy (Basel, Switzerland) · 2024Article
- Turbulent dynamics and whole-brain modeling: toward new clinical applications for traumatic brain injury.Frontiers in neuroinformatics · 2024Review
- The evolution of whole-brain turbulent dynamics during recovery from traumatic brain injury.Network neuroscience (Cambridge, Mass.) · 2024Article
- Complex spatiotemporal oscillations emerge from transverse instabilities in large-scale brain networks.PLoS computational biology · 2023Article
- Pattern breaking: a complex systems approach to psychedelic medicine.Neuroscience of consciousness · 2023Article
- Unifying turbulent dynamics framework distinguishes different brain states.Communications biology · 2022Article
- Editorial: Focus feature on consciousness and cognition.Network neuroscience (Cambridge, Mass.) · 2022Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Psychedelic drugs show promise as safe and effective treatments for neuropsychiatric disorders, yet their mechanisms of action are not fully understood. A fundamental hypothesis is that psychedelics work by dose-dependently changing the functional hierarchy of brain dynamics, but it is unclear whether different psychedelics act similarly. Here, we investigated the changes in the brain's functional hierarchy associated with two different psychedelics (LSD and psilocybin). Using a novel turbulence framework, we were able to determine the vorticity, that is, the local level of synchronization, that allowed us to extend the standard global time-based measure of metastability to become a local-based measure of both space and time. This framework produced detailed signatures of turbulence-based hierarchical change for each psychedelic drug, revealing consistent and discriminate effects on a higher level network, that is, the default mode network. Overall, our findings directly support a prior hypothesis that psychedelics modulate (i.e., "compress") the functional hierarchy and provide a quantification of these changes for two different psychedelics. Implications for therapeutic applications of psychedelics are discussed.
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