ArticleNetwork neuroscience (Cambridge, Mass.)2022
Functional network antagonism and consciousness.
Article in Network neuroscience (Cambridge, Mass.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Cerebellar hypermetabolism disrupts fronto-cerebellar resting-state functional connectivity and associated executive compensation.Translational psychiatry · 2026Article
- Competitive interactions shape mammalian brain network dynamics and computation.Nature neuroscience · 2026Article
- A thalamic perspective of (un)consciousness in pharmacological and pathological states in humans.Brain communications · 2026Article
- The role of coupling among brain regions between the default mode network and the "Mesocircuit" Model in arousal in disorders of consciousness.Frontiers in neurology · 2026Article
- Convergent and divergent spatial topographies of individualized brain functional networks and their developmental origins.Psychoradiology · 2026Article
- Preservation of anticorrelated brain networks predicts recovery after traumatic brain injury.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Voxel-Wise or Region-Wise Nuisance Regression for Functional Connectivity Analyses: Does It Matter?Human brain mapping · 2025Article
- Bridging local and global dynamics: a biologically grounded model for cooperative and competitive interactions in the brain.bioRxiv : the preprint server for biology · 2025Article
- Do individuals with disorders of consciousness dream and mind wander? Implications for improving diagnosis and understanding patient wellbeing.Neuroscience of consciousness · 2025Article
- Antagonistic behavior of brain networks mediated by low-frequency oscillations: electrophysiological dynamics during internal-external attention switching.Communications biology · 2024Article
- Explaining recovery from coma with multimodal neuroimaging.Journal of neurology · 2024Observational
- Temporospatial Nestedness in Consciousness: An Updated Perspective on the Temporospatial Theory of Consciousness.Entropy (Basel, Switzerland) · 2023Review
- Editorial: Focus feature on consciousness and cognition.Network neuroscience (Cambridge, Mass.) · 2022Article
- Understanding cognitive control in aging: A brain network perspective.Frontiers in aging neuroscience · 2022Review
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Authors and funding
6 authors.
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Abstract
Spontaneous brain activity changes across states of consciousness. A particular consciousness-mediated configuration is the anticorrelations between the default mode network and other brain regions. What this antagonistic organization implies about consciousness to date remains inconclusive. In this Perspective Article, we propose that anticorrelations are the physiological expression of the concept of segregation, namely the brain's capacity to show selectivity in the way areas will be functionally connected. We postulate that this effect is mediated by the process of neural inhibition, by regulating global and local inhibitory activity. While recognizing that this effect can also result from other mechanisms, neural inhibition helps the understanding of how network metastability is affected after disrupting local and global neural balance. In combination with relevant theories of consciousness, we suggest that anticorrelations are a physiological prior that can work as a marker of preserved consciousness. We predict that if the brain is not in a state to host anticorrelations, then most likely the individual does not entertain subjective experience. We believe that this link between anticorrelations and the underlying physiology will help not only to comprehend how consciousness happens, but also conceptualize effective interventions for treating consciousness disorders in which anticorrelations seem particularly affected.
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