ArticleAlzheimer's & dementia (Amsterdam, Netherlands)
Prediction of dementia risk from multimodal repeated measures: The added value of brain MRI biomarkers.
Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- The Role of Clinical, Plasma, and Imaging Biomarkers in Assessing Future Dementia Risk in Individuals With Subjective Cognitive Decline.Neurology · 2026Observational
- Brain magnetic resonance imaging biomarkers for future frailty; sub-study of FINGER trial.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Observational
- Abnormal coordination of executive control network and default mode network in cognitive impairment after deep nuclei intracerebral hemorrhage.Frontiers in neurology · 2026Article
- Concurrent brain structural and functional alterations related to cognition in patients with cerebral small vessel disease.Neuroradiology · 2025Article
- Prediction of dementia risk from multimodal repeated measures: The added value of brain MRI biomarkers.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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Authors and funding
10 authors.
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Abstract
Abstract: The utility of brain magnetic resonance imaging (MRI) for predicting dementia is debated. We evaluated the added value of repeated brain MRI, including atrophy and cerebral small vessel disease markers, for dementia prediction. We conducted a landmark competing risk analysis in 1716 participants of the French population-based Three-City Study to predict the 5-year risk of dementia using repeated measures of 41 predictors till year 4 of follow-up. Brain MRI markers improved significantly the individual prediction of dementia after accounting for demographics, health measures, and repeated measures of cognition and functional dependency (area under the ROC curve [95% CI] improved from 0.80 [0.79 to 0.82] to 0.83 [0.81 to 0.84]). Nonetheless, accounting for the change over time through repeated MRIs had little impact on predictive abilities. These results highlight the importance of multimodal analysis to evaluate the added predictive abilities of repeated brain MRI for dementia and offer new insights into the predictive performances of various MRI markers. Highlights: We evaluated whether repeated brain volumes and cSVD markers improve dementia prediction.The 5-year prediction of dementia is slightly improved when considering brain MRI markers.Measures of hippocampus volume are the main MRI predictors of dementia.Adjusted on cognition, repeated MRI has poor added value over single MRI for dementia prediction.We utilized a longitudinal analysis that considers error-and-missing-prone predictors, and competing death.
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