Evidence map›Paper›PMID 38799654›Full record

ArticleACS central science2024

A Fast-Binding, Functionally Reversible, COX-2 Radiotracer for CNS PET Imaging.

Michael S Placzek, Daniel K Wilton, Michel Weïwer, Mariah A Manter, Sarah E Reid, Christopher J Meyer, Arthur J Campbell, Besnik Bajrami, Antoine Bigot, Sarah Bricault and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS central science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. A comprehensive review ofMedicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026
    Review
  2. Article
  3. [Acta pharmaceutica Sinica. B · 2025
    Article
  4. RadiolabeledFrontiers in nuclear medicine · 2025
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Michael S PlaczekAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, United States.
Daniel K WiltonDepartment of Neurology and F.M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, United States.
Michel WeïwerCenter for the Development of Therapeutics, Broad Institute of MIT and Harvard, 75 Ames Street, Cambridge, Massachusetts 02142, United States.ORCID https://orcid.org/0000-0002-4897-1450
Mariah A ManterAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, United States.ORCID https://orcid.org/0000-0001-9197-6452
Sarah E ReidAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, United States.
Christopher J MeyerCenter for the Development of Therapeutics, Broad Institute of MIT and Harvard, 75 Ames Street, Cambridge, Massachusetts 02142, United States.
Arthur J CampbellCenter for the Development of Therapeutics, Broad Institute of MIT and Harvard, 75 Ames Street, Cambridge, Massachusetts 02142, United States.
Besnik BajramiCenter for the Development of Therapeutics, Broad Institute of MIT and Harvard, 75 Ames Street, Cambridge, Massachusetts 02142, United States.
Antoine BigotCenter for the Development of Therapeutics, Broad Institute of MIT and Harvard, 75 Ames Street, Cambridge, Massachusetts 02142, United States.
Sarah BricaultAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, United States.
Agathe FayetCenter for the Development of Therapeutics, Broad Institute of MIT and Harvard, 75 Ames Street, Cambridge, Massachusetts 02142, United States.
Arnaud FrouinDepartment of Neurology and F.M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, United States.
Frederick GergitsDepartment of Neurology and F.M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, United States.
Mehak GuptaCenter for the Development of Therapeutics, Broad Institute of MIT and Harvard, 75 Ames Street, Cambridge, Massachusetts 02142, United States.
Wei JiangCenter for the Development of Therapeutics, Broad Institute of MIT and Harvard, 75 Ames Street, Cambridge, Massachusetts 02142, United States.
Michelle MelansonCenter for the Development of Therapeutics, Broad Institute of MIT and Harvard, 75 Ames Street, Cambridge, Massachusetts 02142, United States.
Chiara D RomanoCenter for the Development of Therapeutics, Broad Institute of MIT and Harvard, 75 Ames Street, Cambridge, Massachusetts 02142, United States.
Misha M RileyAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, United States.
Jessica M WangAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, United States.
Hsiao-Ying WeyAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, United States.ORCID https://orcid.org/0000-0002-1425-8489
Florence F WagnerCenter for the Development of Therapeutics, Broad Institute of MIT and Harvard, 75 Ames Street, Cambridge, Massachusetts 02142, United States.
Beth StevensDepartment of Neurology and F.M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, United States.
Jacob M HookerAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, United States.ORCID https://orcid.org/0000-0002-9394-7708

Funding

Genetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI SCOTT Loren POMEROY, MUSTAFA SAHIN · 2021 to 2026
$9.4M
NICHD NIH HHS P50 HD105351
6 · The paper itself

Abstract

Cyclooxygenase-2 (COX-2) is an enzyme that plays a pivotal role in peripheral inflammation and pain via the prostaglandin pathway. In the central nervous system (CNS), COX-2 is implicated in neurodegenerative and psychiatric disorders as a potential therapeutic target and biomarker. However, clinical studies with COX-2 have yielded inconsistent results, partly due to limited mechanistic understanding of how COX-2 activity relates to CNS pathology. Therefore, developing COX-2 positron emission tomography (PET) radiotracers for human neuroimaging is of interest. This study introduces [

Identifiers

PMID38799654
PMCPMC11117721

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.