Evidence map›Paper›PMID 38799550›Full record

ArticleiScience2024

Sufficient water intake maintains the gut microbiota and immune homeostasis and promotes pathogen elimination.

Kensuke Sato, Mariko Hara-Chikuma, Masato Yasui, Joe Inoue, Yun-Gi Kim

Abstract read
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Nurturing gut health: A comprehensive framework.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026
    Review
  2. Article
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  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
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  11. Rehydration rescues Il22Nature communications · 2025
    Article
  12. Food as Medicine for Hypertension: Microbiota as Mediators.Hypertension (Dallas, Tex. : 1979) · 2025
    Review
  13. Article
  14. Article
  15. Review
  16. Influence of Water Delivery Method on the Gut Microbiome in Laboratory Mice (Mus musculus).Journal of the American Association for Laboratory Animal Science : JAALAS · 2025
    Article
  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kensuke SatoResearch Center for Drug Discovery, Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences, Keio University, Tokyo 105-8512, Japan.
Mariko Hara-ChikumaDepartment of Pharmacology, Keio University School of Medicine, Tokyo 160-8582, Japan.
Masato YasuiDepartment of Pharmacology, Keio University School of Medicine, Tokyo 160-8582, Japan.
Joe InoueDivision of Biochemistry, Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences, Keio University, Tokyo 105-8512, Japan.
Yun-Gi KimDepartment of Microbiology, School of Pharmacy, Kitasato University, Tokyo 108-8641, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Water is the most abundant substance in the human body and plays a pivotal role in various bodily functions. While underhydration is associated with the incidence of certain diseases, the specific role of water in gut function remains largely unexplored. Here, we show that water restriction disrupts gut homeostasis, which is accompanied by a bloom of gut microbes and decreased numbers of immune cells, especially T

Indexed as

Biological sciencesImmunologyMicrobiologyMicrobiome

Identifiers

PMID38799550
PMCPMC11126815

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.