Evidence map›Paper›PMID 38799459›Full record

ArticleFrontiers in immunology2024

Pharmacodynamic monitoring by residual gene expression of the nuclear factor of activated T cell-regulated genes in lung transplant recipients and its correlation with tacrolimus blood levels.

Meritxell Boada-Pérez, Victoria Ruiz de Miguel, Marta Erro, Piedad Ussetti, Myriam Aguilar, Raquel Castejón, Silvia Rosado, Roser Escobar-Fornieles, Eva Revilla-López, Carlos Bravo and 6 more

Abstract read
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Meritxell Boada-PérezDepartment of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain.
Victoria Ruiz de MiguelDepartment of Pulmonology, Vall d'Hebron Institut de Recerca, Barcelona, Spain.
Marta ErroDepartment of Pulmonary Medicine, University Hospital Puerta de Hierro, Madrid, Spain.
Piedad UssettiDepartment of Pulmonary Medicine, University Hospital Puerta de Hierro, Madrid, Spain.
Myriam AguilarDepartment of Pulmonary Medicine, University Hospital Puerta de Hierro, Madrid, Spain.
Raquel CastejónInternal Medicine Laboratory, Instituto de Investigación Puerta de Hierro Segovia de Arana, Madrid, Spain.
Silvia RosadoInternal Medicine Laboratory, Instituto de Investigación Puerta de Hierro Segovia de Arana, Madrid, Spain.
Roser Escobar-FornielesDepartment of Pulmonology, Lung Transplant Program, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
Eva Revilla-LópezDepartment of Pulmonology, Lung Transplant Program, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
Carlos BravoDepartment of Pulmonology, Lung Transplant Program, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
Berta Sáez-GiménezDepartment of Pulmonology, Lung Transplant Program, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
Marta Zapata-OrtegaDepartment of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain.
Yolanda Villena-OrtizCentral Laboratory Services, Pharmacology Section, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
Jaume Vima-BofarullCentral Laboratory Services, Pharmacology Section, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
Víctor MonforteDepartment of Pulmonology, Lung Transplant Program, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
Susana Gómez-OllésDepartment of Pulmonology, Vall d'Hebron Institut de Recerca, Barcelona, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Trough blood levels (C Methods: NFAT-RGE and tacrolimus C Results: Tacrolimus C Conclusion: Consequently, a subset of patients within the tacrolimus therapeutic range may be more susceptible to infection or cancer, potentially benefiting from NFAT-RGE and tacrolimus peak level monitoring to tailor their dosage. Further quantitative risk assessment studies are needed to elucidate the relationship between NFAT-RGE and the risk of infection, cancer, or rejection.

Indexed as

Immunosuppressive AgentsLung TransplantationNFATC Transcription FactorsTacrolimusAdultAgedDrug MonitoringFemaleGene Expression RegulationGraft RejectionHumansMaleMiddle AgedT-LymphocytesTransplant RecipientsImmunosuppressive AgentsNFATC Transcription FactorsTacrolimusbiomarkerinfectionpharmacodynamicspharmacokineticsrejectiontacrolimustherapeutic drug monitoring

Identifiers

PMID38799459
PMCPMC11116644

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.