ArticleACS omega2024
Surface-Assisted Laser Desorption/Ionization Mass Spectrometry with a Two-Dimensional Au Nanoparticle Array for Soft Ionization.
Article in ACS omega, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Nanoparticle-assisted strategies in mass spectrometry-based metabolite analysis: recent advances across analytical workflow.Mikrochimica acta · 2025Review
- In-source photocatalytic fragmentations of oligosaccharides in surface-assisted laser desorption/ionization mass spectrometry over titania nanoparticles.RSC advances · 2025Article
- Stepwise Monitoring of Ligand Exchange on Gold Nanorods: From Cetyltrimethylammonium Bromide to Thiol-Functionalized Biocompatible Phosphorylcholine Using Matrix-Free LDI-TOF Mass Spectrometry.Mass spectrometry (Tokyo, Japan) · 2025Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) is a valuable technique for detecting small molecules in environmental and medicinal studies. We investigated dot-like and 2D-array gold nanoparticle-based SALDI-MS substrates that excite surface plasmons and enhance the desorption/ionization of sample molecules via charge transfer between the substrate and sample molecules. We aimed to optimize the nondissociative detection of sample molecules by efficiently transferring energy while suppressing excess internal energy. SALDI-MS measurements using crystal violet (CV) molecules revealed ion intensity and spectral pattern differences between the dot-like and 2D-array substrates. SALDI-MS measurements using dot-like substrates suggested two desorption/ionization processes: internal energy supply and charge transfer between the substrate and sample molecules. However, SALDI-MS measurements using 2D-array substrates suggested that the internal energy supply was suppressed. As a result, the dot-like substrate provided higher desorption/ionization efficiency but increased fragmentation, whereas the 2D-array substrate was suitable for highly sensitive and nondissociative SALDI-MS measurements. This study contributes to the optimization of SALDI-MS measurements and advances our understanding of energy transfer and sample molecule dissociation.
Identifiers
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Registered trials
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