ReviewJournal of pain research2024
A Narrative Review of the Reciprocal Relationship Between Sleep Deprivation and Chronic Pain: The Role of Oxidative Stress.
Review in Journal of pain research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- Association of physical function and sleep with oxidative stress in adults with chronic pain: A pragmatic clinical trial secondary analysis.The Journal of international medical research · 2026Trial
- An explorative cross-sectional study on the association between immunological biomarkers in patients with chronic pain.Brain, behavior, & immunity - health · 2026Article
- Sleep Disturbances in Patients with Complex Regional Pain Syndrome: A Pilot Exploratory Study on Pain Characteristics, Functional Impairment, and Psychological Factors.Brain sciences · 2026Article
- Linking sleep apnea and arthritis in the National Alzheimer Coordinating Center Cohort: A cross-sectional analysis.Medicine · 2026Article
- Sleep architecture and lying behavior in horses across age groups and two housing systems: an overnight non-invasive EEG study.Frontiers in veterinary science · 2026Article
- Effects and Mechanisms of Wrist-Ankle Acupuncture on Inflammatory Pain in the Rat Gastrocnemius Muscle.Journal of pain research · 2026Article
- Central Sensitization Severity in Chronic Low Back Pain: Associations with Sleep, Distress, Cortisol, and Visuospatial Working Memory.Journal of pain research · 2026Article
- Type-specific effects of orofacial pain on sleep quality: a cross-sectional clinical study.Journal of oral & facial pain and headache · 2026Article
- Sleep Quality, Pain, Worry, and Rumination in Fibromyalgia: Results from Mediation Analyses.Journal of clinical medicine · 2025Article
- Research on the Protective Effects and Mechanisms of Gallic Acid Against Cognitive Impairment Induced by Chronic Sleep Deprivation.Nutrients · 2025Article
- Mediation of the frailty index, the relationship between sleep duration and chronic pain in different body regions: insights from the CHARLS cross-sectional study.Journal of orthopaedic surgery and research · 2025Article
- Review
- Latent profiles and determinants of postoperative sleep quality in elective surgery patients.Scientific reports · 2025Article
- The severity of depressive symptoms as a mediator in the sleep-osteoarthritis risk pathway: insights from the ELSA cohort.Frontiers in nutrition · 2025Article
- Bidirectional relationship between pain and sleep disturbance in middle-aged and older adults: evidence from the China health and retirement longitudinal study.Frontiers in psychiatry · 2024Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sleep is crucial for human health, insufficient sleep or poor sleep quality may negatively affect sleep function and lead to a state of sleep deprivation. Sleep deprivation can result in various health problems, including chronic pain. The intricate relationship between sleep and pain is complex and intertwined, with daytime pain affecting sleep quality and poor sleep increasing pain intensity. The article first describes the influence of sleep on the onset and development of pain, and then explores the impact of daytime pain intensity on nighttime sleep quality and subsequent pain thresholds. However, the primary emphasis is placed on the pivotal role of oxidative stress in this bidirectional relationship. Although the exact mechanisms underlying sleep and chronic pain are unclear, this review focuses on the role of oxidative stress. Numerous studies on sleep deprivation have demonstrated that it can lead to varying degrees of increased pain sensitivity, while chronic pain leads to sleep deprivation and further exacerbates pain. Further research on the role of oxidative stress in the mechanism of sleep deprivation-induced pain sensitization seems reasonable. This article comprehensively reviews the current research on the interrelationship between sleep deprivation, pain and the crucial role of oxidative stress.
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Registered trials
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