Evidence map›Paper›PMID 38799226›Full record

ArticleAmerican journal of ophthalmology case reports2024

Crystalline keratopathy following long-term netarsudil therapy.

Olivia W Cummings, Jesús M Meléndez-Montañez, Leah Naraine, Leyla Yavuz Saricay, Hani El Helwe, David Solá-Del Valle

Abstract readCase Reports
In one paragraph

Article in American journal of ophthalmology case reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Netarsudil-associated conjunctival fragility.American journal of ophthalmology case reports · 2026
    Article
  2. Netarsudil-associated conjunctival pigmentation.American journal of ophthalmology case reports · 2025
    Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Olivia W CummingsWarren Alpert Medical School of Brown University, Providence, RI, USA.
Jesús M Meléndez-MontañezPonce School of Medicine, Ponce Health Sciences University, Ponce, PR, USA.
Leah NaraineGlaucoma Service, Massachusetts Eye, and Ear, Harvard Medical School, Department of Ophthalmology, Boston, MA, USA.
Leyla Yavuz SaricayCornea Service, Massachusetts Eye, and Ear, Harvard Medical School, Department of Ophthalmology, Boston, MA, USA.
Hani El HelweGlaucoma Service, Massachusetts Eye, and Ear, Harvard Medical School, Department of Ophthalmology, Boston, MA, USA.
David Solá-Del ValleGlaucoma Service, Massachusetts Eye, and Ear, Harvard Medical School, Department of Ophthalmology, Boston, MA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: This case report highlights a possible association between netarsudil use and crystalline keratopathy. Observations: Presented here is the case of a 72-year-old woman with primary open-angle glaucoma (POAG) who developed corneal crystalline keratopathy after taking netarsudil for 24 months. The patient's medical history was significant for dry eye syndrome, bilateral ptosis with surgical repair, and atopy (including asthma and various ocular and systemic allergies). The patient had previously undergone surgical repair for bilateral ptosis as well. During the interval between two routine visits, this patient experienced worsening vision with associated eye irritation. Further examination revealed crystal deposits on the anterior corneal surface in the left eye, the only eye undergoing netarsudil treatment. Conclusions and importance: Long-term netarsudil use may be associated with crystalline keratopathy in the anterior stroma, with the potential to cause sight-threatening vision loss if located in the visual axis.

Indexed as

Crystalline keratopathyDrug-related keratopathyNetarsudilOcular surface diseaseRhopressa

Identifiers

PMID38799226
PMCPMC11126778

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.