Evidence map›Paper›PMID 38799178›Full record

ArticleInternational journal of pharmaceutics: X2024

Fine excipient materials in carrier-based dry powder inhalation formulations: The interplay of particle size and concentration effects.

Mustafa M A Elsayed, Iman M Alfagih, Katrina Brockbank, Fawaz Alheibshy, Alhassan H Aodah, Raisuddin Ali, Khaled Almansour, Ahmed O Shalash

Abstract read
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In one paragraph

Article in International journal of pharmaceutics: X, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mustafa M A ElsayedDepartment of Pharmaceutics, College of Pharmacy, University of Ha'il, Ha'il, Saudi Arabia.
Iman M AlfagihDepartment of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Katrina BrockbankFreeman Technology Ltd., Tewkesbury, United Kingdom.
Fawaz AlheibshyDepartment of Pharmaceutics, College of Pharmacy, University of Ha'il, Ha'il, Saudi Arabia.
Alhassan H AodahAdvanced Diagnostics and Therapeutics Institute, Health Sector, King Abdulaziz City for Science and Technology (KACST), Riyadh, Saudi Arabia.
Raisuddin AliDepartment of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Khaled AlmansourDepartment of Pharmaceutics, College of Pharmacy, University of Ha'il, Ha'il, Saudi Arabia.
Ahmed O ShalashSchool of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Queensland, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The contributions of fine excipient materials to drug dispersibility from carrier-based dry powder inhalation (DPI) formulations are well recognized, although they are not completely understood. To improve the understanding of these contributions, we investigated the influences of the particle size of the fine excipient materials on characteristics of carrier-based DPI formulations. We studied two particle size grades of silica microspheres, with volume median diameters of 3.31 μm and 8.14 μm, as fine excipient materials. Inhalation formulations, each composed of a lactose carrier material, one of the fine excipient materials (2.5% or 15.0%

Indexed as

CarrierCritical material attributesDry powder inhalationFine excipient materialMixing energyPowder rheologyQuality-by-design (QbD)

Identifiers

PMID38799178
PMCPMC11127535

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.