Evidence map›Paper›PMID 38799055›Full record

ArticlePeerJ2024

Dental pulp stem cells ameliorate D-galactose-induced cardiac ageing in rats.

Gehan El-Akabawy, Sherif Othman Fathy El-Kersh, Ahmed Othman Fathy Othman El-Kersh, Shaimaa Nasr Amin, Laila Ahmed Rashed, Noha Abdel Latif, Ahmed Elshamey, Mohamed Abdallah Abd El Megied Abdallah, Ibrahim G Saleh, Zaw Myo Hein and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Decoding Dental Stem Cell Aging: Mechanisms, Therapeutic Strategies, and Beyond.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Gehan El-AkabawyDepartment of Basic Medical Sciences, College of Medicine, Ajman University, Ajman, United Arab Emirates.
Sherif Othman Fathy El-KershFaculty of Medicine, Galala University, Suez, Egypt.
Ahmed Othman Fathy Othman El-KershDepartment of Periodontology, Faculty of Dentistry, Kafr El Sheikh University, Kafr El Sheikh, Egypt.
Shaimaa Nasr AminDepartment of Anatomy, Physiology and Biochemistry, Faculty of Medicine, The Hashemite University, Zarqa, Jordan.
Laila Ahmed RashedDepartment of Medical Biochemistry, Faculty of Medicine, Cairo University, Cairo, Egypt.
Noha Abdel LatifDepartment of Medical Pharmacology, Faculty of Medicine, Cairo University, Cairo, Egypt.
Ahmed ElshameySamanoud General Hospital, Samannoud City, Samanoud, Gharbia, Egypt.
Mohamed Abdallah Abd El Megied AbdallahDepartment of Paediatrics, Cairo University, Faculty of Medicine, Cairo, Egypt.
Ibrahim G SalehDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt.
Zaw Myo HeinDepartment of Basic Medical Sciences, College of Medicine, Ajman University, Ajman, United Arab Emirates.
Ibrahim El-SerafiDepartment of Basic Medical Sciences, College of Medicine, Ajman University, Ajman, United Arab Emirates.
Nabil EidDepartment of Anatomy, Division of Human Biology, School of Medicine, International Medical University, Kuala Lumpur, Malaysia.

Funding

Deanship of Research and Graduate Studies, Ajman University, UAE
6 · The paper itself

Abstract

Background: Ageing is a key risk factor for cardiovascular disease and is linked to several alterations in cardiac structure and function, including left ventricular hypertrophy and increased cardiomyocyte volume, as well as a decline in the number of cardiomyocytes and ventricular dysfunction, emphasizing the pathological impacts of cardiomyocyte ageing. Dental pulp stem cells (DPSCs) are promising as a cellular therapeutic source due to their minimally invasive surgical approach and remarkable proliferative ability. Aim: This study is the first to investigate the outcomes of the systemic transplantation of DPSCs in a D-galactose (D-gal)-induced rat model of cardiac ageing. Methods. Thirty 9-week-old Sprague-Dawley male rats were randomly assigned into three groups: control, ageing (D-gal), and transplanted groups (D-gal + DPSCs). D-gal (300 mg/kg/day) was administered intraperitoneally daily for 8 weeks. The rats in the transplantation group were intravenously injected with DPSCs at a dose of 1 × 10 Results: The transplanted cells migrated to the heart, differentiated into cardiomyocytes, improved cardiac function, upregulated Sirt1 expression, exerted antioxidative effects, modulated connexin-43 expression, attenuated cardiac histopathological alterations, and had anti-senescent and anti-apoptotic effects. Conclusion: Our results reveal the beneficial effects of DPSC transplantation in a cardiac ageing rat model, suggesting their potential as a viable cell therapy for ageing hearts.

Indexed as

Dental PulpGalactoseMyocytes, CardiacRats, Sprague-DawleyAgingAnimalsApoptosisCell DifferentiationConnexin 43Disease Models, AnimalMaleRatsSirtuin 1Stem CellsStem Cell TransplantationConnexin 43GalactoseSirt1 protein, ratSirtuin 1Cardiac agingDental pulp stem cellD-galactoseRat model

Identifiers

PMID38799055
PMCPMC11127642

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.