Evidence map›Paper›PMID 38798899›Full record

ArticleOpen forum infectious diseases2024

Reactivation of Multidrug-Resistant HSV-1 in a Post-Allogenic Hematopoietic Stem Cell Transplant Patient: Dynamic Detection of the Rare A605V Mutation by Next-Generation Sequencing.

Shuxuan Zheng, Lidewij L W Rümke, Bruno Tello Rubio, Malbert R C Rogers, Geerte L van Sluis, Jürgen H E Kuball, Annelies Riezebos-Brilman, Robert Jan Lebbink, Frans M Verduyn Lunel

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In one paragraph

Article in Open forum infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Shuxuan ZhengDepartment of Medical Microbiology, UMC Utrecht, Utrecht, The Netherlands.ORCID https://orcid.org/0000-0003-1176-2601
Lidewij L W RümkeDepartment of Medical Microbiology, UMC Utrecht, Utrecht, The Netherlands.
Bruno Tello RubioDepartment of Medical Microbiology, UMC Utrecht, Utrecht, The Netherlands.
Malbert R C RogersDepartment of Medical Microbiology, UMC Utrecht, Utrecht, The Netherlands.
Geerte L van SluisDepartment of Haematology UMC Utrecht, Utrecht, The Netherlands.
Jürgen H E KuballDepartment of Haematology UMC Utrecht, Utrecht, The Netherlands.
Annelies Riezebos-BrilmanDepartment of Medical Microbiology, UMC Utrecht, Utrecht, The Netherlands.
Robert Jan LebbinkDepartment of Medical Microbiology, UMC Utrecht, Utrecht, The Netherlands.
Frans M Verduyn LunelDepartment of Medical Microbiology, UMC Utrecht, Utrecht, The Netherlands.ORCID https://orcid.org/0000-0002-9787-1827

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present an immunocompromised patient with a multiresistant herpes simplex virus-1 reactivation with a rare mutation (A605V) in the viral DNA polymerase gene. Next-generation sequencing suggests the presence of multiple drug-resistant strains before treatment and altered ratios during treatment, affecting the clinical response to aciclovir and foscarnet.

Indexed as

aciclovirfoscarnetHSV-1multidrug resistancestem cell transplantation

Identifiers

PMID38798899
PMCPMC11127484

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.