Evidence map›Paper›PMID 38798882›Full record

ArticleDigital health

Exploring the impact of computer game playing on cognitive function, Alzheimer's disease risk, and brain-derived neurotrophic factor levels: Basic evidence from Mendelian randomization.

Jinlong Wu, Zhenwei Mao, Zhanbing Ren, Wanli Zang, Haodong Tian, Li Huang, Haowei Liu, Feiyang Liu, Li Peng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Digital health. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jinlong WuCollege of Physical Education, Southwest University, Chongqing, China.ORCID https://orcid.org/0000-0002-0694-3144
Zhenwei MaoCollege of Physical Education, Southwest University, Chongqing, China.
Zhanbing RenCollege of Physical Education, Shenzhen University, Shenzhen, China.
Wanli ZangPostgraduate School, Harbin Sport University, Harbin, China.
Haodong TianCollege of Physical Education, Southwest University, Chongqing, China.
Li HuangCollege of Physical Education, Southwest University, Chongqing, China.
Haowei LiuCollege of Physical Education, Southwest University, Chongqing, China.
Feiyang LiuCollege of Physical Education, Southwest University, Chongqing, China.
Li PengCollege of Physical Education, Southwest University, Chongqing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The potential positive impact of computer game playing on cognitive function and its potential role in reducing the risk of Alzheimer's disease (AD) has been suggested. However, current observational studies have certain limitations. We utilized Mendelian randomization (MR) alongside extensive genome-wide association study (GWAS) data to examine the relationship between computer game playing, cognitive function, risk of AD, and levels of brain-derived neurotrophic factor (BDNF). Methods: We collected datasets on computer game playing, cognition function, risk of AD, and BDNF level from the IEU Open GWAS project. Causal effects were assessed using various MR methods, including inverse variance weighted (IVW), weighted median, MR-Egger, simple mode, and weighted mode. To ensure the accuracy of the results, sensitivity analyses were conducted. Results: Our analysis revealed a significant association between computer game playing and cognitive function ( Conclusion: The results of our study indicate that engaging in computer game playing may confer a safeguarding influence on cognitive function. This underscores the potential advantages associated with computer gaming. Nevertheless, given the constraints inherent in our research, further investigation is warranted to substantiate our findings and delve into the underlying mechanisms.

Indexed as

Alzheimer’s diseaseBDNFcognition functionComputer gaming playingMendelian randomization

Identifiers

PMID38798882
PMCPMC11128171

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.