SynthesisNarra J2024
A comparative analysis between next-generation sequencing and conventional culture method to detect empyema-associated microorganisms: A systematic review.
Synthesis in Narra J, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Microbial Etiology of Empyema Thoracis in Children: A Systematic Review and Meta-Analysis.Indian pediatrics · 2026Pooled it
- Comparison of Molecular Methods With Culture for Identifying Microbial Etiology in Pediatric Empyema Thoracis: A Systematic Review of Diagnostic Test Accuracy.Indian pediatrics · 2026Pooled it
- Clinical Characteristics and Machine Learning-Based Severity Classification ofInfection and drug resistance · 2026Article
- Presence of bacterial DNA in synovial fluid from the temporomandibular joint in patients with temporomandibular joint disorders.Frontiers in oral health · 2026Article
- Clinical Features and Diagnostic Challenges ofInfection and drug resistance · 2026Article
- The species, distribution, resistance of donor-derived pathogens and their impact on solid organ transplant recipients.Frontiers in immunology · 2026Article
- A Practical Approach to Pleural Infection.Pulmonary therapy · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Empyema poses a significant global health concern, yet identifying responsible bacteria remains elusive. Recent studies question the efficacy of conventional pleural fluid culture in accurately identifying empyema-causing bacteria. The aim of this study was to compare diagnostic capabilities of next-generation sequencing (NGS) with conventional pleural fluid culture in identifying empyema-causing bacteria. Five databases (Google Scholar, Science Direct, Cochrane, Research Gate, and PubMed) were used to search studies comparing conventional pleural fluid culture with NGS for identifying empyema-causing bacteria using keywords. Positive results identified through conventional pleural fluid culture and NGS were extracted. In addition, bacterial profiles identified by NGS were also documented. Joanna-Briggs Institute (JBI) critical appraisal tool was employed to assess quality of included studies. Descriptive analysis was employed to present outcome of interests. From five databases, three studies, with 354 patients, were included. Findings from three studies showed that NGS outperformed conventional pleural fluid culture in detecting empyema-causing bacteria even in culture-negative samples. Moreover, dominant bacterial profiles identified through NGS included
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