Abiraterone in Classic Congenital Adrenal Hyperplasia: Results of Medical Therapy Before Adrenalectomy.

Bronwyn G A Stuckey, Deila Dedic, Rui Zhang, Amira Rabbah, Adina F Turcu, Richard J Auchus

Abstract readCase Reports

In one paragraph

Article in JCEM case reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Integrated mapping resolves pathogenicity of 11Journal of the Endocrine Society · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Bronwyn G A StuckeyKeogh Institute for Medical Research, Nedlands, Western Australia 6009, Australia.ORCID https://orcid.org/0000-0002-9109-9864

Deila DedicMurdoch Endocrinology, Murdoch, Western Australia 6150, Australia.

Rui ZhangDepartment of Biochemistry, PathWest Laboratory Medicine, Nedlands, Western Australia 6009, Australia.ORCID https://orcid.org/0000-0002-2878-3348

Amira RabbahDepartment of Internal Medicine/Division of Metabolism, Endocrinology, and Metabolism, University of Michigan, Ann Arbor, MI 48109, USA.

Adina F TurcuDepartment of Internal Medicine/Division of Metabolism, Endocrinology, and Metabolism, University of Michigan, Ann Arbor, MI 48109, USA.ORCID https://orcid.org/0000-0001-9831-6190

Richard J AuchusDepartment of Internal Medicine/Division of Metabolism, Endocrinology, and Metabolism, University of Michigan, Ann Arbor, MI 48109, USA.ORCID https://orcid.org/0000-0001-6815-6181

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present the case of a 20-year-old woman with classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency, with uncontrolled hyperandrogenemia despite supraphysiological glucocorticoid therapy. We used abiraterone acetate, an inhibitor of the 17-hydroxylase/17,20-lyase enzyme, to suppress adrenal androgen synthesis and allow physiological glucocorticoid and mineralocorticoid therapy, as a proof-of-concept, before proceeding to bilateral adrenalectomy. We report the patient's clinical course, the changes in adrenal steroids, and the immunohistochemistry of the adrenals.

Indexed as

21-hydroxylase deficiencyabiraterone acetateadrenalectomyclassic congenital adrenal hyperplasia

Identifiers

PMID38798742

DOI10.1210/jcemcr/luae077

PMCPMC11119162

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.