ArticlebioRxiv : the preprint server for biology2024
Quantitative and systematic NMR measurements of sequence-dependent A-T Hoogsteen dynamics uncovers unique conformational specificity in the DNA double helix.
Akanksha Manghrani, Atul Kaushik Rangadurai, Or Szekely, Bei Liu, Serafima Guseva, Hashim M Al-Hashimi
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
6 authors.
Akanksha ManghraniDepartment of Biochemistry, Duke University School of Medicine, Durham, North Carolina 27705, United States.
Atul Kaushik RangaduraiDepartment of Biochemistry, Duke University School of Medicine, Durham, North Carolina 27705, United States.
Or SzekelyDepartment of Biochemistry, Duke University School of Medicine, Durham, North Carolina 27705, United States.
Bei LiuDepartment of Biochemistry, Duke University School of Medicine, Durham, North Carolina 27705, United States.
Serafima GusevaDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, United States.
Hashim M Al-HashimiDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, United States.
Funding
RM1 Center on Macromolecular Dynamics by NMR Spectroscopy at the New York Structural Biology Center (CoMD/NMR)- Equipment Supplement RequestRM1GM145397 · NIGMS · NEW YORK STRUCTURAL BIOLOGY CENTER · PI ARTHUR G PALMER · 2022 to 2026
$8.3MRole of DNA structural dynamics in mutagenesis and oncogenesisR01GM089846 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Hashim M Al-Hashimi · 2010 to 2026
$5.2M900 MHz NMR Spectrometer for Structural BiologyP41GM066354 · NIGMS · NEW YORK STRUCTURAL BIOLOGY CENTER · PI COWBURN, DAVID · 2002 to 2006
$4.7MEXTRAMURAL RESEARCH FACILITIES CONSTRUCTIONC06RR015495 · NCRR · NEW YORK STRUCTURAL BIOLOGY CENTER · PI RIFKIND, RICHARD A · 2000 to 2000
$2.0MAcquisition of a 900 MHz NMR Spectrometer Console and ProbesS10OD030373 · OD · NEW YORK STRUCTURAL BIOLOGY CENTER · PI PALMER, ARTHUR G · 2021 to 2021
$1.7MAcquisition of 700 MHz NMR SpectrometerS10OD018509 · OD · NEW YORK STRUCTURAL BIOLOGY CENTER · PI PALMER, ARTHUR G · 2015 to 2015
$1.1MNCRR NIH HHS C06 RR015495NIGMS NIH HHS P41 GM066354NIGMS NIH HHS R01 GM089846NIGMS NIH HHS RM1 GM145397NIH HHS S10 OD018509NIH HHS S10 OD030373
6 · The paper itselfAbstract
The propensities to form lowly-populated short-lived conformations of DNA could vary with sequence, providing an important source of sequence-specificity in biochemical reactions. However, comprehensively measuring how these dynamics vary with sequence is challenging. Using
Indexed as
Conformational ensembleDNA damageDNA dynamicsmutational signaturessequence-specific recognition
Identifiers
PMID38798635
PMCPMC11118333
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