Evidence map›Paper›PMID 38798607›Full record

ArticlebioRxiv : the preprint server for biology2024

ZNF143 binds DNA and stimulates transcripstion initiation to activate and repress direct target genes.

Jinhong Dong, Thomas G Scott, Rudradeep Mukherjee, Michael J Guertin

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Jinhong DongCenter for Cell Analysis and Modeling, University of Connecticut, Farmington, Connecticut, United States of America.
Thomas G ScottDepartment of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia, United States of America.
Rudradeep MukherjeeCenter for Cell Analysis and Modeling, University of Connecticut, Farmington, Connecticut, United States of America.
Michael J GuertinCenter for Cell Analysis and Modeling, University of Connecticut, Farmington, Connecticut, United States of America.ORCID 0000-0001-7148-3538

Funding

Mechanisms of coordinate gene regulation by transcription factorsR35GM128635 · NIGMS · UNIVERSITY OF VIRGINIA · PI Michael Joseph Guertin · 2018 to 2026
$3.4M
NIGMS NIH HHS R35 GM128635
6 · The paper itself

Abstract

Transcription factors bind to sequence motifs and act as activators or repressors. Transcription factors interface with a constellation of accessory cofactors to regulate distinct mechanistic steps to regulate transcription. We rapidly degraded the essential and ubiquitously expressed transcription factor ZNF143 to determine its function in the transcription cycle. ZNF143 facilitates RNA Polymerase initiation and activates gene expression. ZNF143 binds the promoter of nearly all its activated target genes. ZNF143 also binds near the site of genic transcription initiation to directly repress a subset of genes. Although ZNF143 stimulates initiation at ZNF143-repressed genes (i.e. those that increase expression upon ZNF143 depletion), the molecular context of binding leads to

Indexed as

ActivatorBifunctionalContext SpecificInitiationRepressorTranscription FactorZNF143

Identifiers

PMID38798607
PMCPMC11118474

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.