Evidence map›Paper›PMID 38798540›Full record

ArticlebioRxiv : the preprint server for biology2024

Temporal Single Cell Analysis of Leukemia Microenvironment Identifies Taurine-Taurine Transporter Axis as a Key Regulator of Myeloid Leukemia.

Benjamin J Rodems, Sonali Sharma, Cameron D Baker, Christina M Kaszuba, Takashi Ito, Jane L Liesveld, Laura M Calvi, Michael W Becker, Craig T Jordan, John M Ashton and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Benjamin J RodemsDepartment of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY 14642, USA.
Sonali SharmaDepartment of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY 14642, USA.
Cameron D BakerGenomics Research Center, University of Rochester Medical Center, Rochester, NY 14642, USA.
Christina M KaszubaWilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY 14642, USA.
Takashi ItoDepartment of Bioscience and Technology, Graduate School of Bioscience and Technology, Fukui Prefectural University, Fukui, Japan.
Jane L LiesveldWilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY 14642, USA.
Laura M CalviWilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY 14642, USA.
Michael W BeckerWilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY 14642, USA.
Craig T JordanDivision of Hematology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
John M AshtonDepartment of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY 14642, USA.
Jeevisha BajajDepartment of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY 14642, USA.ORCID 0000-0002-8411-6056

Funding

Mechanisms of marrow microenvironmental aging and their impact of progression of clonal hematopoiesisR01AG079556 · NIA · UNIVERSITY OF ROCHESTER · PI Laura M Calvi, JANE L. LIESVELD · 2022 to 2026
$2.7M
Efferocytosis by Bone Marrow Stromal Cells and Bone AgingR01AG076786 · NIA · UNIVERSITY OF ROCHESTER · PI Laura M Calvi, Roman Eliseev · 2022 to 2026
$2.4M
Targeting Microenvironmental Signals in Myeloid MalignanciesR01CA266617 · NCI · UNIVERSITY OF ROCHESTER · PI Jeevisha Bajaj · 2022 to 2026
$2.4M
Modulation of aged hematopoietic stem cell nichesR01AG046293 · NIA · UNIVERSITY OF ROCHESTER · PI BECKER, MICHAEL W, CALVI, LAURA M · 2013 to 2017
$954k
Defining and Manipulating the Endothelial Niche in Myelodysplastic SyndromesR01DK133131 · NIDDK · UNIVERSITY OF ROCHESTER · PI BAJAJ, JEEVISHA · 2022 to 2024
$684k
NCI NIH HHS R01 CA266617NIA NIH HHS R01 AG046293NIA NIH HHS R01 AG076786NIA NIH HHS R01 AG079556NIDDK NIH HHS R01 DK133131
6 · The paper itself

Abstract

Signals from the microenvironment are known to be critical for development, sustaining adult stem cells, and for oncogenic progression. While candidate niche-driven signals that can promote cancer progression have been identified

Identifiers

PMID38798540
PMCPMC11118281

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.