ArticlebioRxiv : the preprint server for biology2024
Multi-organ structural homogeneity of amyloid fibrils in ATTRv-T60A amyloidosis patients, revealed by Cryo-EM.
Maria Del Carmen Fernandez-Ramirez, Binh A Nguyen, Virender Singh, Shumaila Afrin, Bret Evers, Parker Basset, Lanie Wang, Maja Pękała, Yasmin Ahmed, Preeti Singh and 4 more
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In one paragraphArticle in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
14 authors.
Maria Del Carmen Fernandez-RamirezCenter for Alzheimer's and Neurodegenerative Diseases, Department of Biophysics, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center (UTSW), Dallas, TX, USA.ORCID 0000-0002-3265-5242 Binh A NguyenCenter for Alzheimer's and Neurodegenerative Diseases, Department of Biophysics, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center (UTSW), Dallas, TX, USA.ORCID 0000-0001-7055-8809 Virender SinghCenter for Alzheimer's and Neurodegenerative Diseases, Department of Biophysics, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center (UTSW), Dallas, TX, USA.ORCID 0000-0002-6720-8784 Shumaila AfrinCenter for Alzheimer's and Neurodegenerative Diseases, Department of Biophysics, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center (UTSW), Dallas, TX, USA.ORCID 0000-0002-8671-1617 Bret EversDepartment of Pathology, University of Texas Southwestern Medical Center (UTSW), Dallas, TX, USA.
Parker BassetCenter for Alzheimer's and Neurodegenerative Diseases, Department of Biophysics, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center (UTSW), Dallas, TX, USA.ORCID 0009-0001-5162-7212 Lanie WangCenter for Alzheimer's and Neurodegenerative Diseases, Department of Biophysics, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center (UTSW), Dallas, TX, USA.ORCID 0000-0003-2532-7889 Maja PękałaCenter for Alzheimer's and Neurodegenerative Diseases, Department of Biophysics, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center (UTSW), Dallas, TX, USA.ORCID 0000-0001-9463-8141 Yasmin AhmedCenter for Alzheimer's and Neurodegenerative Diseases, Department of Biophysics, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center (UTSW), Dallas, TX, USA.ORCID 0000-0002-5115-2085 Preeti SinghCenter for Alzheimer's and Neurodegenerative Diseases, Department of Biophysics, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center (UTSW), Dallas, TX, USA.ORCID 0000-0003-2508-5613 Jacob CanepaGraduate School of Biomedical Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Aleksandra WosztylGraduate School of Biomedical Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Yang LiDepartment of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Lorena SaelicesCenter for Alzheimer's and Neurodegenerative Diseases, Department of Biophysics, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center (UTSW), Dallas, TX, USA.ORCID 0000-0002-1904-2150 Funding
Pacific Northwest Center for Cryo-EM - Screening supplementU24GM129547 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI EVANS, JAMES E, GOUAUX, JAMES E · 2018 to 2023
$54.8MClosing the gap between structural biology and translational science for amyloid diseasesDP2HL163810 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI SAELICES GOMEZ, LORENA · 2021 to 2024
$2.5MTEM for UT Southwestern Electron Microscopy Core FacilityS10OD021685 · OD · UT SOUTHWESTERN MEDICAL CENTER · PI LUBY-PHELPS, KATHERINE J · 2017 to 2017
$398kSEM for UT Southwestern EM Core FacilityS10OD020103 · OD · UT SOUTHWESTERN MEDICAL CENTER · PI LUBY-PHELPS, KATHERINE J · 2015 to 2015
$306kNHLBI NIH HHS DP2 HL163810NIGMS NIH HHS U24 GM129547NIH HHS S10 OD020103NIH HHS S10 OD021685
6 · The paper itselfAbstract
ATTR amyloidosis is a degenerative disorder characterized by the systemic deposition of the protein transthyretin. These amyloid aggregates of transthyretin (ATTR) can deposit in different parts of the body causing diverse clinical manifestations. Our laboratory aims to investigate a potential relationship between the different genotypes, organ of deposition, clinical phenotypes, and the structure of ATTR fibrils. Using cryo-electron microscopy, we have recently described how the neuropathic related mutations ATTRv-I84S and ATTRv-V122∆ can drive structural polymorphism in
Identifiers
PMID38798519
PMCPMC11118364
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