Evidence map›Paper›PMID 38798517›Full record

ArticlebioRxiv : the preprint server for biology2024

Asymmetric stem cell division maintains genetic heterogeneity of tissue cells.

Muhammed Burak Bener, Boris M Slepchenko, Mayu Inaba

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Muhammed Burak BenerDepartment of Cell Biology, University of Connecticut School of Medicine, Farmington, CT 06030.
Boris M SlepchenkoDepartment of Cell Biology, University of Connecticut School of Medicine, Farmington, CT 06030.
Mayu InabaDepartment of Cell Biology, University of Connecticut School of Medicine, Farmington, CT 06030.ORCID 0000-0002-8508-7461

Funding

Mechanistic Modeling of Cellular SystemsR24GM137787 · NIGMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI Pedro Mendes, Ion I. Moraru · 2020 to 2026
$8.9M
Nanotube-mediated regulation of niche-stem cell signalingR35GM128678 · NIGMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI Mayu Inaba-Oguro · 2018 to 2026
$3.3M
NIGMS NIH HHS R24 GM137787NIGMS NIH HHS R35 GM128678
6 · The paper itself

Abstract

Within a given tissue, the stem cell niche provides the microenvironment for stem cells suitable for their self-renewal. Conceptually, the niche space constrains the size of a stem-cell pool, as the cells sharing the niche compete for its space. It has been suggested that either neutral- or non-neutral-competition of stem cells changes the clone dynamics of stem cells. Theoretically, if the rate of asymmetric division is high, the stem cell competition is limited, thus suppressing clonal expansion. However, the effects of asymmetric division on clone dynamics have never been experimentally tested. Here, using the

Identifiers

PMID38798517
PMCPMC11118488

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.