Evidence map›Paper›PMID 38798510›Full record

ArticleResearch square2024

Gut commensals require Peyer's patches to induce protective systemic IgA responses.

Joshua R Harris, Victoria Zoccoli-Rodriguez, Mara S Delaney, Tania N Cruz, Brian T Gaudette, Joel R Wilmore

Abstract readPreprint
In one paragraph

Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Joshua R HarrisDepartment of Microbiology and Immunology, SUNY Upstate Medical University, Syracuse, NY.
Victoria Zoccoli-RodriguezDepartment of Microbiology and Immunology, SUNY Upstate Medical University, Syracuse, NY.
Mara S DelaneyDepartment of Microbiology and Immunology, SUNY Upstate Medical University, Syracuse, NY.
Tania N CruzDepartment of Microbiology and Immunology, SUNY Upstate Medical University, Syracuse, NY.
Brian T GaudetteDepartment of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH.
Joel R WilmoreDepartment of Microbiology and Immunology, SUNY Upstate Medical University, Syracuse, NY.ORCID https://orcid.org/0000-0002-2797-5604

Funding

Mechanisms of commensal bacteria induced humoral immunityR35GM147560 · NIGMS · UPSTATE MEDICAL UNIVERSITY · PI Joel R Wilmore · 2022 to 2026
$2.1M
Defining the role of T-bet in systemic IgAF31AI174655 · NIAID · UPSTATE MEDICAL UNIVERSITY · PI ZOCCOLI-RODRIGUEZ, VICTORIA E · 2023 to 2023
$48k
NIAID NIH HHS F31 AI174655NIGMS NIH HHS R35 GM147560
6 · The paper itself

Abstract

Gut educated IgA secreting plasma cells that disseminate beyond the mucosa and into systemic tissues have been described as providing beneficial effects from disease in several contexts. Several bacteria have been implicated in the induction of systemic IgA, however the mechanisms that result in differential levels of induction by each bacterial species are still unknown. Here we show, the commensal bacteria,

Identifiers

PMID38798510
PMCPMC11118714

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.