Evidence map›Paper›PMID 38798454›Full record

ArticlebioRxiv : the preprint server for biology2025

EZH2-driven immune evasion at disease presentation defines a targetable high-risk subset of acute leukemia exemplified by t(16;21) FUS::ERG AML.

Nathaniel J Buteyn, Samantha J LaMantia, Connor G Burke, Vincent J Sartori, Eve Deering-Gardner, Zachary J DeBruine, Dahlya Kamarudin, Darrell P Chandler, Alexander C Monovich, Monika W Perez and 6 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. [Childhood acute myeloid leukemia withZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Nathaniel J ButeynDepartment of Epigenetics, Van Andel Research Institute, Grand Rapids, MI.ORCID 0000-0001-5738-3784
Samantha J LaMantiaDepartment of Epigenetics, Van Andel Research Institute, Grand Rapids, MI.
Connor G BurkeDepartment of Epigenetics, Van Andel Research Institute, Grand Rapids, MI.
Vincent J SartoriDepartment of Epigenetics, Van Andel Research Institute, Grand Rapids, MI.ORCID 0000-0001-6591-029X
Eve Deering-GardnerDepartment of Epigenetics, Van Andel Research Institute, Grand Rapids, MI.ORCID 0009-0009-4133-8343
Zachary J DeBruineDepartment of Epigenetics, Van Andel Research Institute, Grand Rapids, MI.ORCID 0000-0003-2234-4827
Dahlya KamarudinDepartment of Epigenetics, Van Andel Research Institute, Grand Rapids, MI.
Darrell P ChandlerDepartment of Epigenetics, Van Andel Research Institute, Grand Rapids, MI.ORCID 0000-0002-6462-0941
Alexander C MonovichDepartment of Pathology, University of Michigan, Ann Arbor, MI.ORCID 0000-0002-7589-1026
Monika W PerezDepartment of Genome Sciences, University of Washington, Seattle, WA.ORCID 0000-0003-4019-9790
Joanna S YiDepartment of Pediatrics, Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, TX.ORCID 0000-0002-0914-8728
Rhonda E RiesClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA.ORCID 0000-0002-3702-7923
Todd A AlonzoChildren's Oncology Group, Monrovia, CA.ORCID 0000-0002-6772-6581
Russell Jh RyanDepartment of Pathology, University of Michigan, Ann Arbor, MI.ORCID 0000-0001-8174-3962
Soheil MeshinchiClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA.ORCID 0000-0002-6276-4423
Timothy J TricheDepartment of Epigenetics, Van Andel Research Institute, Grand Rapids, MI.ORCID 0000-0003-4869-8826

Funding

NCTN BIQSFP ANBL1531 (NRT)U10CA180886 · NCI · PUBLIC HEALTH INSTITUTE · PI Douglas S. Hawkins · 2014 to 2026
$390.6M
COG SDMC - Statistics CoreU10CA180899 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TODD A ALONZO · 2014 to 2026
$132.8M
Cancer Epigenetics Training (CET) ProgramT32CA251066 · NCI · VAN ANDEL RESEARCH INSTITUTE · PI Scott Rothbart · 2021 to 2026
$2.4M
The roles of genetics, hormones, and gender in sexually dimorphic immune responseR01AI171984 · NIAID · VAN ANDEL RESEARCH INSTITUTE · PI KRAWCZYK, CONNIE, PROKOP, JEREMY WILLIAM · 2022 to 2024
$1.4M
Dissecting the role of germline genetic variation and viral exposures as determinants of hematological disease predispositionR03CA290259 · NCI · VAN ANDEL RESEARCH INSTITUTE · PI TRICHE, TIMOTHY J. · 2024 to 2024
$336k
NCI NIH HHS R03 CA290259NCI NIH HHS T32 CA251066NCI NIH HHS U10 CA180886NCI NIH HHS U10 CA180899NIAID NIH HHS R01 AI171984
6 · The paper itself

Abstract

The past 25 years of clinical trials have produced few improvements in pediatric AML (pAML) outcomes. This is acutely evident in patients with t(16;21)(p11;q22), yielding

Identifiers

PMID38798454
PMCPMC11118270

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.