Evidence map›Paper›PMID 38798439›Full record

ArticlebioRxiv : the preprint server for biology2024

Perivascular adipose tissue remodeling impairs vasoreactivity in thermoneutral-housed rats.

Melissa M Henckel, Ji Hye Chun, Leslie A Knaub, Gregory B Pott, Georgia E James, Kendall S Hunter, Robin Shandas, Lori A Walker, Jane E-B Reusch, Amy C Keller

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Melissa M HenckelDivision of Endocrinology, Metabolism & Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO 80045.
Ji Hye ChunDivision of Endocrinology, Metabolism & Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO 80045.
Leslie A KnaubDivision of Endocrinology, Metabolism & Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO 80045.
Gregory B PottDivision of Endocrinology, Metabolism & Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO 80045.
Georgia E JamesUniversity of Iowa, Iowa City, IA 52242.
Kendall S HunterDepartment of Bioengineering, University of Colorado Anschutz Medical Campus, Aurora, CO 80045.
Robin ShandasDepartment of Bioengineering, University of Colorado Anschutz Medical Campus, Aurora, CO 80045.
Lori A WalkerDivision of Cardiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045.
Jane E-B ReuschDivision of Endocrinology, Metabolism & Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO 80045.
Amy C KellerDivision of Endocrinology, Metabolism & Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO 80045.

Funding

CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR025780 · NCRR · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2008 to 2011
$61.3M
Role of Microvascular insulin resistance and cardiorespiratory fitness in diabetesR01DK124344 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI ZHENQI LIU, JUDITH G. REGENSTEINER · 2021 to 2026
$3.5M
Targeting Microvascular Contributors to Impaired Functional Exercise Capacity in DiabetesI01BX002046 · VA · VA EASTERN COLORADO HEALTH CARE SYSTEM · PI REUSCH, JANE E · 2014 to 2024
–
Repair of Vascular Contractility and Mitochondrial Function by NOS RecouplingIK2BX003185 · VA · VA EASTERN COLORADO HEALTH CARE SYSTEM · PI KELLER, AMY CELESTE · 2017 to 2022
–
BLRD VA I01 BX002046BLRD VA IK2 BX003185NCRR NIH HHS UL1 RR025780NIDDK NIH HHS R01 DK124344
6 · The paper itself

Abstract

Objective: Vascular pathology, characterized by impaired vasoreactivity and mitochondrial respiration, differs between the sexes. Housing rats under thermoneutral (TN) conditions causes vascular dysfunction and perturbed metabolism. We hypothesized that perivascular adipose tissue (PVAT), a vasoregulatory adipose depot with brown adipose tissue (BAT) phenotype, remodels to a white adipose (WAT) phenotype in rats housed at TN, driving diminished vasoreactivity in a sex-dependent manner. Methods: Male and female Wistar rats were housed at either room temperature (RT) or TN. Endpoints included changes in PVAT morphology, vasoreactivity in vessels with intact PVAT or transferred to PVAT of the oppositely-housed animal, vessel stiffness, vessel mitochondrial respiration and cellular signaling. Results: Remodeling of PVAT was observed in rats housed at TN; animals in this environment showed PVAT whitening and displayed diminished aortae vasodilation (p<0.05), different between the sexes. Juxtaposing PVAT from RT rats onto aortae from TN rats in females corrected vasodilation (p<0.05); this did not occur in males. In aortae of all animals housed at TN, mitochondrial respiration was significantly diminished in lipid substrate experiments (p<0.05), and there was significantly less expression of peNOS (p<0.001). Conclusions: These data are consistent with TN-induced remodeling of PVAT, notably associated with sex-specific blunting of vasoreactivity, diminished mitochondrial respiration, and altered cellular signaling.

Indexed as

adiponectinCardiovascular diseasemitochondria

Identifiers

PMID38798439
PMCPMC11118269

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.