ArticlemedRxiv : the preprint server for health sciences2025
Genome-wide association studies in a large Korean cohort identify novel quantitative trait loci for 36 traits and illuminate their genetic architectures.
Yon Ho Jee, Ying Wang, Keum Ji Jung, Ji-Young Lee, Heejin Kimm, Rui Duan, Alkes L Price, Alicia R Martin, Peter Kraft
Abstract readPreprint
In one paragraphArticle in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
9 authors.
Ying WangAnalytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA.
Keum Ji JungInstitute for Health Promotion, Department of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea.
Ji-Young LeeInstitute for Health Promotion, Department of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea.
Heejin KimmInstitute for Health Promotion, Department of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea.
Rui DuanDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA.
Alkes L PriceDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Alicia R MartinAnalytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA.ORCID 0000-0003-0241-3522 Funding
Methods for Genome-wide Association Studies in Admixed PopulationsR01HG006399 · NHGRI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI PRICE, ALKES L · 2011 to 2024
$6.3MLeveraging Prospective Cancer Epidemiology Cohorts and Novel Methods to Improve Polygenic Risk ScoresU01CA261339 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Fei Chen, David V Conti · 2021 to 2026
$5.2MFederated and transfer learning methods for cross-ancestry and cross-phenotype integration of genomic datasetsR01GM148494 · NIGMS · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Rui Duan · 2023 to 2026
$1.7MGeneralizing polygenic risk prediction methods across populations for insights into psychiatric diseaseR00MH117229 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI MARTIN, ALICIA · 2020 to 2022
$724kNCI NIH HHS U01 CA261339NHGRI NIH HHS R01 HG006399NIGMS NIH HHS R01 GM148494NIMH NIH HHS R00 MH117229
6 · The paper itselfAbstract
Genome-wide association studies (GWAS) have been predominantly conducted in populations of European ancestry, limiting opportunities for biological discovery in diverse populations. We report GWAS findings from 153,950 individuals across 36 quantitative traits in the Korean Cancer Prevention Study-II (KCPS2) Biobank. We discovered 301 novel genetic loci in KCPS2, including an association between thyroid-stimulating hormone and
Indexed as
complex traitsgenetic architecturegenome-wide association studyKorean population
Identifiers
PMID38798434
PMCPMC11118625
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