Evidence map›Paper›PMID 38798417›Full record

ArticlemedRxiv : the preprint server for health sciences2024

The mutagenic forces shaping the genomic landscape of lung cancer in never smokers.

Marcos Díaz-Gay, Tongwu Zhang, Phuc H Hoang, Azhar Khandekar, Wei Zhao, Christopher D Steele, Burçak Otlu, Shuvro P Nandi, Raviteja Vangara, Erik N Bergstrom and 21 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Marcos Díaz-GayDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Tongwu ZhangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Phuc H HoangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Azhar KhandekarDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Wei ZhaoDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Christopher D SteeleDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Burçak OtluDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Shuvro P NandiDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Raviteja VangaraDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Erik N BergstromDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Mariya KazachkovaDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Oriol PichCancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.
Charles SwantonCancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.
Chao Agnes HsiungInstitute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan.
I-Shou ChangNational Institute of Cancer Research, National Health Research Institutes, Zhunan, Taiwan.
Maria Pik WongQueen Mary Hospital, The University of Hong Kong, Hong Kong, China.
Kin Chung LeungDepartment of Pathology, The University of Hong Kong, Hong Kong, China.
Jian SangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
John McElderryDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Lixing YangBen May Department for Cancer Research, Department of Human Genetics, Comprehensive Cancer Center, The University of Chicago, Chicago, IL, USA.
Martin A NowakDepartment of Mathematics, Harvard University, Cambridge, MA, USA.
Jianxin ShiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Nathaniel RothmanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
David C WedgeManchester Cancer Research Centre, The University of Manchester, Manchester, UK.
Robert HomerYale Surgery Pathology Department, Yale University, New Haven, CT, USA.
Soo-Ryum YangDepartment of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, USA.
Qing LanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Bin ZhuDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Ludmil B AlexandrovDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0003-3596-4515
Maria Teresa LandiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.

Funding

Studies of Genetic and Environmental EpidemiologyZIACP101231 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI LANDI, MARIA · 2018 to 2025
$23.6M
Predoctoral and Postdoctoral Training in Cancer Cell BiologyT32CA067754 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JEAN Y.J. WANG · 1995 to 2026
$6.5M
Detecting Mutational Signatures of Environmental Mutagens in Heathy Individuals for Personalized Cancer PreventionR01ES032547 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ALEXANDROV, LUDMIL B · 2021 to 2025
$3.4M
Mapping immuno-genomic drivers of the head and neck precancer invasive-disease transitionU01CA290479 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ludmil B Alexandrov, Jorge Silvio Gutkind · 2023 to 2026
$3.1M
Comprehensive identification of germline-somatic interactionsR01CA269919 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ludmil B Alexandrov, Hannah Kathryn Carter · 2022 to 2026
$2.2M
Intramural NIH HHS ZIA CP101231NCI NIH HHS R01 CA269919NCI NIH HHS T32 CA067754NCI NIH HHS U01 CA290479NIEHS NIH HHS R01 ES032547
6 · The paper itself

Abstract

Lung cancer in never smokers (LCINS) accounts for up to 25% of all lung cancers and has been associated with exposure to secondhand tobacco smoke and air pollution in observational studies. Here, we evaluate the mutagenic exposures in LCINS by examining deep whole-genome sequencing data from a large international cohort of 871 treatment-naïve LCINS recruited from 28 geographical locations within the Sherlock-

Identifiers

PMID38798417
PMCPMC11118654

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.