Evidence map›Paper›PMID 38798392›Full record

ArticlebioRxiv : the preprint server for biology2024

Maximizing photon utilization in spectroscopic single-molecule localization microscopy using symmetrically dispersed dual-wedge prisms.

Wei-Hong Yeo, Benjamin Brenner, Youngseop Lee, Junghun Kweon, Cheng Sun, Hao F Zhang

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Wei-Hong YeoDepartment of Biomedical Engineering, Northwestern University, Evanston IL 60201, USA.ORCID 0000-0003-2181-1673
Benjamin BrennerDepartment of Biomedical Engineering, Northwestern University, Evanston IL 60201, USA.
Youngseop LeeDepartment of Biomedical Engineering, Northwestern University, Evanston IL 60201, USA.ORCID 0000-0003-1978-3431
Junghun KweonDepartment of Biomedical Engineering, Northwestern University, Evanston IL 60201, USA.ORCID 0000-0002-7538-7663
Cheng SunDepartment of Mechanical Engineering, Northwestern University, Evanston IL 60201, USA.ORCID 0000-0002-2744-0896
Hao F ZhangDepartment of Biomedical Engineering, Northwestern University, Evanston IL 60201, USA.ORCID 0000-0001-5089-1196

Funding

Technology Development UnitU54CA268084 · NCI · NORTHWESTERN UNIVERSITY · PI Daniela E Matei · 2022 to 2026
$10.0M
Photoactivatable Fluorophores for High-Throughput Multiplexed Tracking of Single-Molecules in Live CellsR01GM143397 · NIGMS · UNIVERSITY OF MIAMI CORAL GABLES · PI RAYMO, FRANCISCO M · 2022 to 2025
$1.4M
Intrinsic-contrast super-resolution imaging of DNA at 2-nm resolutionR01GM139151 · NIGMS · NORTHWESTERN UNIVERSITY · PI ZHANG, HAO F · 2020 to 2023
$1.3M
Development of spectroscopic Single-Molecule Localization MicroscopyR01GM140478 · NIGMS · NORTHWESTERN UNIVERSITY · PI SUN, CHENG, ZHANG, HAO F · 2021 to 2024
$1.2M
NCI NIH HHS U54 CA268084NIGMS NIH HHS R01 GM139151NIGMS NIH HHS R01 GM140478NIGMS NIH HHS R01 GM143397
6 · The paper itself

Abstract

Single-molecule localization microscopy (SMLM) enables super-resolution imaging on conventional fluorescent microscopes. Spectroscopic SMLM (sSMLM) further allows highly multiplexed super-resolution imaging. We report an easy-to-implement symmetrically dispersed dual-wedge prism (SDDWP)-sSMLM design that maximizes photon utilization. We first symmetrically dispersed photons to the -1

Identifiers

PMID38798392
PMCPMC11118294

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.