Evidence map›Paper›PMID 38798358›Full record

ArticlebioRxiv : the preprint server for biology2024

CPT2 mediated fatty acid oxidation is dispensable for humoral immunity.

Meilu Li, Xian Zhou, Xingxing Zhu, Yanfeng Li, Taro Hitosugi, Yuzhen Li, Hu Zeng

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Meilu LiDivision of Rheumatology, Department of Medicine, Mayo Clinic Rochester, MN 55905, USA.
Xian ZhouDivision of Rheumatology, Department of Medicine, Mayo Clinic Rochester, MN 55905, USA.
Xingxing ZhuDivision of Rheumatology, Department of Medicine, Mayo Clinic Rochester, MN 55905, USA.ORCID 0000-0001-8411-319X
Yanfeng LiDivision of Rheumatology, Department of Medicine, Mayo Clinic Rochester, MN 55905, USA.
Taro HitosugiDepartment of Oncology, Mayo Clinic, Rochester, MN 55905, USA.
Yuzhen LiDepartment of Dermatology, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150001, P. R. China.
Hu ZengDivision of Rheumatology, Department of Medicine, Mayo Clinic Rochester, MN 55905, USA.ORCID 0000-0002-9909-7732

Funding

Context dependent amino acid availability and sensing determines humoral immunityR01AI162678 · NIAID · MAYO CLINIC ROCHESTER · PI Hu Zeng · 2022 to 2026
$2.3M
Role of CPT1A as a lysine succinyltransferase in tumorigenesisR01CA225680 · NCI · MAYO CLINIC ROCHESTER · PI HITOSUGI, TARO · 2018 to 2022
$1.8M
Immune Checkpoint Inhibition and humoral immune response in systemic autoimmunityR01AR077518 · NIAMS · MAYO CLINIC ROCHESTER · PI ZENG, HU · 2021 to 2025
$1.7M
NCI NIH HHS R01 CA225680NIAID NIH HHS R01 AI162678NIAMS NIH HHS R01 AR077518
6 · The paper itself

Abstract

B cell activation is accompanied by dynamic metabolic reprogramming, supported by a multitude of nutrients that include glucose, amino acids and fatty acids. While several studies have indicated that fatty acid mitochondrial oxidation is critical for immune cell functions, contradictory findings have been reported. Carnitine palmitoyltransferase II (CPT2) is a critical enzyme for long-chain fatty acid oxidation in mitochondria. Here, we test the requirement of CPT2 for humoral immunity using a mouse model with a lymphocyte specific deletion of CPT2. Stable

Identifiers

PMID38798358
PMCPMC11118297

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.