Evidence map›Paper›PMID 38798323›Full record

ArticlebioRxiv : the preprint server for biology2024

SARS-CoV-2 Infection of Salivary Glands Compromises Oral Antifungal Innate Immunity and Predisposes to Oral Candidiasis.

Areej A Alfaifi, Tristan W Wang, Paola Perez, Ahmed S Sultan, Timothy F Meiller, Peter Rock, David E Kleiner, Daniel S Chertow, Stephen M Hewitt, Billel Gasmi and 5 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Areej A AlfaifiDepartment of Oncology and Diagnostic Sciences, School of Dentistry, University of Maryland Baltimore, Maryland, United States of America.
Tristan W WangDepartment of Oncology and Diagnostic Sciences, School of Dentistry, University of Maryland Baltimore, Maryland, United States of America.
Paola PerezSalivary Disorders Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, United States of America.
Ahmed S SultanDepartment of Oncology and Diagnostic Sciences, School of Dentistry, University of Maryland Baltimore, Maryland, United States of America.
Timothy F MeillerDepartment of Oncology and Diagnostic Sciences, School of Dentistry, University of Maryland Baltimore, Maryland, United States of America.
Peter RockDepartment of Anesthesia, School of Medicine, University of Maryland Baltimore, Maryland, United States of America.
David E KleinerLaboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America.
Daniel S ChertowCritical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
Stephen M HewittLaboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America.
Billel GasmiLaboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America.
Sydney SteinCritical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
Sabrina RamelliCritical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
Daniel MartinGenomics and Computational Biology Core, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, United States of America.
Blake M WarnerSalivary Disorders Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, United States of America.
Mary Ann Jabra-RizkDepartment of Oncology and Diagnostic Sciences, School of Dentistry, University of Maryland Baltimore, Maryland, United States of America.ORCID 0000-0002-4425-3873

Funding

Genomic and Computational Biology Support for NIDCD Intramural ResearchZICDC000086 · NIDCD · NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS · PI MORELL, ROBERT J · 2015 to 2025
$19.8M
Postmortem PathologyZICBC010685 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI KLEINER, DAVID ERWIN · 2009 to 2025
$14.3M
INTEGRATIVE MECHANISMS OF CORTICAL NEURONSR01DC000086 · NIDCD · YALE UNIVERSITY · PI SHEPHERD, GORDON · 1989 to 2010
$3.6M
Clinical Investigations Of Sjogren's SyndromeZ01DE000704 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI ILLEI, GABOR · 2002 to 2008
$3.0M
Impact of SARS-CoV-2 mediated salivary gland dysfunction on secreted salivary antimicrobial peptides and the risk for oral opportunistic infectionsR21DE031888 · NIDCR · UNIVERSITY OF MARYLAND BALTIMORE · PI JABRA-RIZK, MARY ANN Y · 2022 to 2023
$425k
Clinical and Molecular Features of Coronavirus Disease 2019ZIACL090070 · CLC · CLINICAL CENTER · PI CHERTOW, DANIEL S · 2020 to 2025
$0k
Intramural NIH HHS Z01 DE000704Intramural NIH HHS ZIA CL090070Intramural NIH HHS ZIC DC000086NIDCD NIH HHS R01 DC000086NIDCR NIH HHS R21 DE031888
6 · The paper itself

Abstract

Saliva contains antimicrobial peptides considered integral components of host innate immunity, and crucial for protection against colonizing microbial species. Most notable is histatin-5 which is exclusively produced in salivary glands with uniquely potent antifungal activity against the opportunistic pathogen

Identifiers

PMID38798323
PMCPMC11118411

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.