Evidence map›Paper›PMID 38798313›Full record

ArticlebioRxiv : the preprint server for biology2024

FGF21 acts in the brain to drive macronutrient-specific changes in behavioral motivation and brain reward signaling.

Md Shahjalal H Khan, Sora Q Kim, Robert C Ross, Florina Corpodean, Redin A Spann, Diana A Albarado, Sun O Fernandez-Kim, Blaise Clarke, Hans-Rudolf Berthoud, Heike Münzberg and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Md Shahjalal H KhanPennington Biomedical Research Center, Baton Rouge, LA 70808.
Sora Q KimPennington Biomedical Research Center, Baton Rouge, LA 70808.
Robert C RossPennington Biomedical Research Center, Baton Rouge, LA 70808.
Florina CorpodeanPennington Biomedical Research Center, Baton Rouge, LA 70808.
Redin A SpannPennington Biomedical Research Center, Baton Rouge, LA 70808.
Diana A AlbaradoPennington Biomedical Research Center, Baton Rouge, LA 70808.
Sun O Fernandez-KimPennington Biomedical Research Center, Baton Rouge, LA 70808.
Blaise ClarkePennington Biomedical Research Center, Baton Rouge, LA 70808.
Hans-Rudolf BerthoudPennington Biomedical Research Center, Baton Rouge, LA 70808.
Heike MünzbergPennington Biomedical Research Center, Baton Rouge, LA 70808.
David H McDougalPennington Biomedical Research Center, Baton Rouge, LA 70808.
Yanlin HePennington Biomedical Research Center, Baton Rouge, LA 70808.
Sangho YuPennington Biomedical Research Center, Baton Rouge, LA 70808.
Vance L AlbaughPennington Biomedical Research Center, Baton Rouge, LA 70808.
Paul SotoDepartment of Psychology, Louisiana State University, Baton Rouge, LA 70810.ORCID 0000-0003-2930-6479
Christopher D MorrisonPennington Biomedical Research Center, Baton Rouge, LA 70808.ORCID 0000-0002-5492-102X

Funding

Research BaseP30DK072476 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI ROBERT A KESTERSON · 2005 to 2026
$26.5M
The role of maternal obesity-driven inflammation and adverse pregnancy outcomes in a mouse model of preeclampsiaP20GM135002 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Timothy Allerton · 2020 to 2026
$18.4M
Training in Obesity ResearchT32DK064584 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI CORBY K MARTIN, Christopher D Morrison · 2003 to 2026
$5.3M
Neural circuits coordinating protein intake: Role of FGF21R01DK123083 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI MORRISON, CHRISTOPHER D · 2020 to 2024
$1.6M
Sable Systems Promethion for Mouse Metabolic AnalysisS10OD023703 · OD · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI MORRISON, CHRISTOPHER D · 2017 to 2017
$626k
Central FGF21-mediated control of energy expenditure.F32DK130544 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI SPANN, REDIN A · 2021 to 2022
$134k
NIDDK NIH HHS F32 DK130544NIDDK NIH HHS P30 DK072476NIDDK NIH HHS R01 DK123083NIDDK NIH HHS T32 DK064584NIGMS NIH HHS P20 GM135002NIH HHS S10 OD023703
6 · The paper itself

Abstract

Dietary protein restriction induces adaptive changes in food preference, increasing protein consumption over carbohydrates or fat. We investigated whether motivation and reward signaling underpin these preferences. In an operant task, protein-restricted male mice responded more for liquid protein rewards, but not carbohydrate, fat, or sweet rewards compared to non-restricted mice. The protein restriction-induced increase in operant responding for protein was absent in

Identifiers

PMID38798313
PMCPMC11118293

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.