Evidence map›Paper›PMID 38798239›Full record

ArticleEndocrinology and metabolism (Seoul, Korea)2024

Diagnostic Accuracy of Preoperative Radiologic Findings in Papillary Thyroid Microcarcinoma: Discrepancies with the Postoperative Pathologic Diagnosis and Implications for Clinical Outcomes.

Ying Li, Seul Ki Kwon, Hoonsung Choi, Yoo Hyung Kim, Sunyoung Kang, Kyeong Cheon Jung, Jae-Kyung Won, Do Joon Park, Young Joo Park, Sun Wook Cho

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Article in Endocrinology and metabolism (Seoul, Korea), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Ying LiDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Seul Ki KwonDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Hoonsung ChoiDepartment of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea.
Yoo Hyung KimDepartment of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
Sunyoung KangDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Kyeong Cheon JungDepartment of Pathology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
Jae-Kyung WonDepartment of Pathology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
Do Joon ParkDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Young Joo ParkDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Sun Wook ChoDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.

Funding

Ministry of Education 5120200513755Ministry of Health and Welfare HC19C0103Ministry of Health and Welfare HI19C0481National Research Foundation of KoreaPatient-Centered Clinical Research Coordinating Center
6 · The paper itself

Abstract

backgruoundThe diagnostic accuracy of preoperative radiologic findings in predicting the tumor characteristics and clinical outcomes of papillary thyroid microcarcinoma (PTMC) was evaluated across all risk groups.

methodsIn total, 939 PTMC patients, comprising both low-risk and non-low-risk groups, who underwent surgery were enrolled. The preoperative tumor size and lymph node metastasis (LNM) were evaluated by ultrasonography within 6 months before surgery and compared with the postoperative pathologic findings. Discrepancies between the preoperative and postoperative tumor sizes were analyzed, and clinical outcomes were assessed.

resultsThe agreement rate between radiological and pathological tumor size was approximately 60%. Significant discrepancies were noted, including an increase in tumor size in 24.3% of cases. Notably, in 10.8% of patients, the postoperative tumor size exceeded 1 cm, despite being initially classified as 0.5 to 1.0 cm based on preoperative imaging. A postoperative tumor size >1 cm was associated with aggressive pathologic factors such as multiplicity, microscopic extrathyroidal extension, and LNM, as well as a higher risk of distant metastasis. In 30.1% of patients, LNM was diagnosed after surgery despite not being suspected before the procedure. This group was characterized by smaller metastatic foci and lower risks of distant metastasis or recurrence than patients with LNM detected both before and after surgery.

conclusionAmong all risk groups of PTMCs, a subset showed an increase in tumor size, reaching 1 cm after surgery. These cases require special consideration due to their association with adverse clinical outcomes, including an elevated risk of distant metastasis.

Indexed as

Carcinoma, PapillaryThyroid NeoplasmsAdultAgedFemaleHumansLymphatic MetastasisMaleMiddle AgedPostoperative PeriodPreoperative PeriodPrognosisRetrospective StudiesThyroidectomyTreatment OutcomeTumor BurdenDiscrepancyLymph node metastasisPapillary thyroid microcarcinomaRadiologic diagnosisTumor size

Identifiers

PMID38798239
PMCPMC11220223

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