Recent Advances in Fluorescent Probes for G-quadruplex DNAs / RNAs.

Hongyan Yang, Ping Xu, Fei Pan, Jinhong Gao, Libo Yuan, Kui Lu

Abstract readReview

In one paragraph

Review in Mini reviews in medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Molecular Tools for Precision Targeting and Detection of G-Quadruplex Structures.Molecules (Basel, Switzerland) · 2025
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hongyan YangCollege of Food Science and Engineering, Henan University of Technology, Zhengzhou, 450001, China.

Ping XuCollege of Chemistry, Zhengzhou University, Zhengzhou, 450001, China.

Fei PanState Key Laboratory of Resource Insects, Institute of Apicultural Research, Chinese Academy of Agricultural Sciences, Beijing, 100093, China.

Jinhong GaoCollege of Food Science and Engineering, Henan University of Technology, Zhengzhou, 450001, China.

Libo YuanCollege of Food Science and Engineering, Henan University of Technology, Zhengzhou, 450001, China.

Kui LuCollege of Food Science and Engineering, Henan University of Technology, Zhengzhou, 450001, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Guanine-quadruplexes (G4s) are high-level structures formed by the folding of guaninerich nucleic acid sequences. G4s play important roles in various physiological processes, such as gene transcription, replication, recombination, and maintenance of chromosomal stability. Specific and sensitive monitoring of G4s lays the foundation for further understanding the structure, content, distribution, and function of G4s in organisms, which is important for the treatment and diagnosis of diseases. Moreover, visualization of G4s will provide new ideas for developing antitumor strategies targeting G4s. The design and development of G4-specific ligands are challenging due to the subtle differences in the structure of G4s. This review focuses on the progress of research on G4 fluorescent probes and their binding mechanisms to G4s. Finally, the challenges and future prospects for better detection and targeting of G4s in different organisms are discussed. This paper provides ideas for the development of novel G4 fluorescent probes.

Indexed as

DNAFluorescent DyesG-QuadruplexesRNAHumansDNAFluorescent DyesRNAcancer diagnosticscell imagingfluorescent probesGuanine-quadruplexestumor therapy.

Identifiers

PMID38798221

DOI10.1039/C6SC00001K

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.