Evidence map›Paper›PMID 38798204›Full record

ReviewCurrent diabetes reviews2025

Comorbidity of Depression and Diabetes: A Literature Review on Systemic Flaws in Healthcare and the Benefits of Collaborative Diagnosis and Treatment in Primary Care Settings.

Pranay Wal, Pankaj Kumar, Harsh Bhardwaj, Komal Sharma, Arpan Kumar Tripathi, Arpit Gupta, Ankita Wal, Mukesh Chandra Sharma

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current diabetes reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Pranay WalPSIT-Pranveer Singh Institute of Technology (Pharmacy) NH 19 Agra Kanpur Bhauti, Kanpur, 209305, UP, India.
Pankaj KumarAdesh Institute of Pharmacy and Biomedical sciences, Adesh University, NH-7, Barnala Road, Bathinda, 151001, India.
Harsh BhardwajDepartment of Pharmaceutical Chemistry, Anand College of Pharmacy (SGI) Keetham, Agra, 282007, India.
Komal SharmaBhupal Nobles Institute of Pharmaceutical Sciences, Udaipur, Rajasthan, 313001, India.
Arpan Kumar TripathiKIPS, Shri Shankaracharya Professional University, Bhilai, Chhattisgarh, India.
Arpit GuptaPSIT-Pranveer Singh Institute of Technology (Pharmacy) NH 19 Agra Kanpur Bhauti, Kanpur, 209305, UP, India.
Ankita WalPSIT-Pranveer Singh Institute of Technology (Pharmacy) NH 19 Agra Kanpur Bhauti, Kanpur, 209305, UP, India.
Mukesh Chandra SharmaSchool of Pharmacy, Devi Ahilya Vishwavidalaya, Indore, 452001, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe increasing specialization and dispersion of healthcare systems have led to a shortage of resources to address comorbidities. Patients with coexisting mental and physical conditions are disadvantaged, as medical providers often only focus on the patient's mental illness while neglecting their physical needs, resulting in poorer health outcomes.

objectiveThis study aimed to shed light on the systemic flaws in healthcare systems that contribute to suboptimal health outcomes in individuals with comorbid diseases, including depression and diabetes. This paper also discusses the clinical and economic benefits of collaborative methods for diagnosing and treating depressive disorders in primary care settings.

methodsA comprehensive literature review of the relationship between depression and diabetes was conducted. The outcomes of the literature review were carefully analyzed. Several databases were searched using keywords such as "diabetes," "depression," "comorbidity," "prevalence," "epidemiology," and "risk factors" using Google Scholar and PubMed as search engines. The review and research papers written between 1961 and 2023 were our main focus.

resultsThis study revealed improved depressive symptoms and better blood sugar and blood pressure control. Additionally, individuals with comorbid depression and diabetes have higher direct and secondary medical costs. Antidepressants and psychological interventions are equally effective in treating depressive symptoms in patients with diabetes, although they have conflicting effects on glycemic control. For individuals with comorbid diabetes and depression, clear care pathways, including a multidisciplinary team, are essential for achieving the best medical and mental health outcomes.

conclusionCoordinated healthcare solutions are necessary to reduce the burden of illness and improve therapeutic outcomes. Numerous pathophysiological mechanisms interact with one another and may support the comorbidities of T2DM, and depressive disorders could exacerbate the course of both diseases.

Indexed as

DepressionDiabetes MellitusPrimary Health CareComorbidityHumanscomorbiditydepressionDiabetesepidemiologyprevalencerisk factors.

Identifiers

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.