ArticleCNS neuroscience & therapeutics2024
Exploring the potential relationship between short sleep risks and cognitive function from the perspective of inflammatory biomarkers and cellular pathways: Insights from population-based and mice studies.
Article in CNS neuroscience & therapeutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 3 of them syntheses that pooled it.
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Who cites it
56 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Spectrum of mental health among students: A scientometric analysis of 20 years of research on depression and anxiety.Medicine · 2025Pooled it
- Evidence map of traditional Chinese exercises.Frontiers in public health · 2024Pooled it
- Impact of exercise type, duration, and intensity on depressive symptoms in older adults: a systematic review and meta-analysis.Frontiers in psychology · 2024Pooled it
- Scoping review on the relationship between microRNAs (miRNAs) and short sleep disorder or insomnia with short sleep duration.Sleep medicine: X · 2026Article
- Exploring the role of β2-microglobulin in the relationship between physical activity and DNAm-predicted PhenoAge: Evidence from a population-based and mice single-cell RNA-sequencing study.Journal of advanced research · 2026Article
- Association Between Systemic Inflammation Response Index and Specific Depressive Symptoms: Evidence From a Cross-Sectional Survey.Brain and behavior · 2026Article
- Impact of Sleep Quality on Cognitive Function in Elderly Patients With Alzheimer's Disease.Actas espanolas de psiquiatria · 2026Article
- Oral microbiome diversity shapes the association between leisure-time physical activity and cognitive function among older adults.iScience · 2026Article
- Association between social activities and cardiovascular diseases: evidence from the CHARLS database.BMC public health · 2026Article
- Sleep deprivation impairs follicular development attributable to granulosa cell pyroptosis mediated by S100A8/A9-driven macrophage M1 polarization.Science advances · 2026Article
- The Lactate Nexus: A Molecular Bridge Linking Physical Activity, Sleep, and Cognitive Enhancement.Biomedicines · 2026Review
- Obstructive Sleep Apnea and Hypercoagulability: Combining Observational and Mendelian Randomization Analyses to Explore Causal Relationships.Nature and science of sleep · 2026Article
- Electroacupuncture Attenuates Neuroinflammation in PCPA-Induced Insomnia Rats by Suppressing the TLR4/MyD88/NF-κB p65 Pathway and M1 Microglial Activation.Neuropsychiatric disease and treatment · 2026Article
- Sleep Disturbances and Sarcopenia in Older Adults: Clinical Associations, Potential Mechanisms, and Management Strategies.International journal of general medicine · 2026Review
- Association of Sleep-related Parenting Practices and Sleep Problems in Preschoolers: A National Multiprovince Survey in China.Nature and science of sleep · 2026Article
- Cognitive profile and inflammatory markers in children and adolescents with specific learning disorder: a cross-sectional study.Frontiers in pediatrics · 2026Article
- Sleep Rhythmicity as a Core Domain of Multidimensional Sleep Health Associated with Cognitive Impairment in Older Men.Nature and science of sleep · 2026Article
- Sleep and neurocognitive function in the geriatric population: a cross-sectional comparison between nursing-home and community-dwelling older adults.Sleep & breathing = Schlaf & Atmung · 2025Article
- Herbal medicine evaluation for reimbursement-based facial palsy (HERB-FP): a retrospective analysis using Korean health insurance claim data 2020-2024.BMC complementary medicine and therapies · 2025Article
- Knowledge, attitudes, and practices (KAP) regarding nutrition among bodybuilders of Zanjan, Northwest of Iran: a cross-sectional study.BMC sports science, medicine & rehabilitation · 2025Article
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Authors and funding
6 authors.
Funding
Abstract
aimsThe molecular mechanism of short-sleep conditions on cognition remains largely unknown. This research aimed to investigate associations between short sleep, inflammatory biomarkers and cognitive function in the US population (NHANES data 2011-2014) and explore cellular mechanisms in mice.
methodsSystemic immune-inflammation index (SII) was calculated using blood-cell based biomarkers. Further, we employed integrated bioinformatics and single-cell transcriptomics (GSE137665) to examine how short sleep exposure influenced the molecular pathways associated with inflammation in the brain. To explore the signaling pathways and biological processes of sleep deprivation, we carried out enrichment analyses utilizing the GO and KEGG databases.
resultsPopulation results showed that, compared with normal sleep group, severe short sleep was associated with lower cognitive ability in all the four tests. Moreover, a higher SII level was correlated with lower scores of cognitive tests. In mice study, elevated activation of the inflammatory pathway was observed in cell subgroups of neurons within the sleep deprivation and recovery sleep cohorts. Additionally, heightened expression of oxidative stress and integrated stress response pathways was noted in GABAergic neurons during sleep deprivation.
conclusionThis study contributed to the understanding of the influence of short sleep on cognitive function and its cellular mechanisms.
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