Evidence map›Paper›PMID 38797973›Full record

ArticleArchives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists2024

Anticholinergic Medication Burden and Cognitive Subtypes in Parkinson's Disease without Dementia.

Lauren G Santos, Lauren E Kenney, Alyssa Ray, Alfredo Paredes, Adrianna M Ratajska, Kara Eversole, Bhavana Patel, Ashley E Rawls, Michael S Okun, Dawn Bowers

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In one paragraph

Article in Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lauren G SantosDepartment of Clinical and Health Psychology, University of Florida, PO Box 100165 Gainesville, FL 32610-0165.ORCID 0000-0003-0454-1704
Lauren E KenneyDepartment of Clinical and Health Psychology, University of Florida, PO Box 100165 Gainesville, FL 32610-0165.
Alyssa RayDepartment of Clinical and Health Psychology, University of Florida, PO Box 100165 Gainesville, FL 32610-0165.
Alfredo ParedesDepartment of Clinical and Health Psychology, University of Florida, PO Box 100165 Gainesville, FL 32610-0165.
Adrianna M RatajskaDepartment of Clinical and Health Psychology, University of Florida, PO Box 100165 Gainesville, FL 32610-0165.
Kara EversoleDepartment of Clinical and Health Psychology, University of Florida, PO Box 100165 Gainesville, FL 32610-0165.
Bhavana PatelNorman Fixel Institute for Neurological Diseases, University of Florida, 3009 SW Williston Road Gainesville, FL 32608.
Ashley E RawlsNorman Fixel Institute for Neurological Diseases, University of Florida, 3009 SW Williston Road Gainesville, FL 32608.
Michael S OkunNorman Fixel Institute for Neurological Diseases, University of Florida, 3009 SW Williston Road Gainesville, FL 32608.
Dawn BowersDepartment of Clinical and Health Psychology, University of Florida, PO Box 100165 Gainesville, FL 32610-0165.

Funding

Interdisciplinary Training in Movement Disorders and NeurorestorationT32NS082168 · NINDS · UNIVERSITY OF FLORIDA · PI Melissa Jo Armstrong, David E Vaillancourt · 2015 to 2026
$2.8M
Brain Drivers, Cognition, and Parkinson's Disease: A Psychometric ApproachF31AG081047 · NIA · UNIVERSITY OF FLORIDA · PI KENNEY, LAUREN · 2023 to 2024
$62k
Cognition in Essential Tremor: A Neuroimaging and Biomarker StudyF31NS131000 · NINDS · UNIVERSITY OF FLORIDA · PI RATAJSKA, ADRIANNA MARTA · 2023 to 2024
$58k
NIA NIH HHS F31 AG081047NIH HHS F31-AG081047NINDS NIH HHS F31 NS131000NINDS NIH HHS T32 NS082168
6 · The paper itself

Abstract

objectiveCognitive changes are heterogeneous in Parkinson's disease (PD). This study compared whether anticholinergic burden drives differences in cognitive domain performance and empirically-derived PD-cognitive phenotypes.

methodA retrospective chart review contained participants (n = 493) who had idiopathic PD without dementia. Participants' medications were scored (0-3) and summed based on the anticholinergic cognitive burden scale (ACBS). We examined the ACBS' relationship to five cognitive domain composites (normative z-scores) and three (K-means clustering based) cognitive phenotypes: cognitively intact, low executive function (EF), and predominately impaired EF/memory. Analyses included Spearman correlations, analysis of covariance, and Pearson chi-squared test.

resultsOverall, phenotypes did not differ in anticholinergic burden, and (after false-discovery-rate corrections) no cognitive domains related. When comparing those above and below the clinically relevant ACBS cutoff (i.e., score ≥3), no significant phenotype or domain differences were found.

conclusionsAnticholinergic medication usage did not drive cognitive performance in a large clinical sample of idiopathic PD without dementia.

Indexed as

Cholinergic AntagonistsParkinson DiseaseAgedAged, 80 and overCognitionCognitive DysfunctionDementiaExecutive FunctionFemaleHumansMaleMiddle AgedNeuropsychological TestsRetrospective StudiesCholinergic AntagonistsAnticholinergic burdenCognitive risk factorsParkinson’s disease

Identifiers

PMID38797973
PMCPMC11586454

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.