Evidence map›Paper›PMID 38797559›Full record

ArticleAddiction biology2024

Longitudinal alcohol-related brain changes in older adults: The Sydney Memory and Ageing Study.

Louise Mewton, Rachel Visontay, Gerard Hughes, Catherine Browning, Wei Wen, Anya Topiwala, Brian Draper, John D Crawford, Henry Brodaty, Perminder S Sachdev

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Addiction biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Louise MewtonThe Matilda Centre for Mental Health and Substance Use, Faculty of Medicine and Health, University of Sydney, Sydney, Australia.ORCID 0000-0002-7812-296X
Rachel VisontayThe Matilda Centre for Mental Health and Substance Use, Faculty of Medicine and Health, University of Sydney, Sydney, Australia.
Gerard HughesCentre for Healthy Brain Ageing, Faculty of Medicine and Health, University of New South Wales, Sydney, Australia.
Catherine BrowningCentre for Healthy Brain Ageing, Faculty of Medicine and Health, University of New South Wales, Sydney, Australia.
Wei WenCentre for Healthy Brain Ageing, Faculty of Medicine and Health, University of New South Wales, Sydney, Australia.
Anya TopiwalaNuffield Department Population Health, Big Data Institute, University of Oxford, Oxford, UK.
Brian DraperCentre for Healthy Brain Ageing, Faculty of Medicine and Health, University of New South Wales, Sydney, Australia.
John D CrawfordCentre for Healthy Brain Ageing, Faculty of Medicine and Health, University of New South Wales, Sydney, Australia.
Henry BrodatyCentre for Healthy Brain Ageing, Faculty of Medicine and Health, University of New South Wales, Sydney, Australia.
Perminder S SachdevCentre for Healthy Brain Ageing, Faculty of Medicine and Health, University of New South Wales, Sydney, Australia.

Funding

Mapping the Neurobiological Risks and Consequences of Alcohol Use in Adolescence and Across the LifespanR01AA030575 · NIAAA · UNIVERSITY OF SYDNEY · PI Louise Mewton, Lindsay Squeglia · 2023 to 2026
$1.2M
National Health and Medical Research Council APP1093083National Health and Medical Research Council ID350833National Health and Medical Research Council ID568969NIAAA NIH HHS R01 AA030575NIH HHS R01AA030575
6 · The paper itself

Abstract

Increases in harmful drinking among older adults indicate the need for a more thorough understanding of the relationship between later-life alcohol use and brain health. The current study investigated the relationships between alcohol use and progressive grey and white matter changes in older adults using longitudinal data. A total of 530 participants (aged 70 to 90 years; 46.0% male) were included. Brain outcomes assessed over 6 years included total grey and white matter volume, as well as volume of the hippocampus, thalamus, amygdala, corpus callosum, orbitofrontal cortex and insula. White matter integrity was also investigated. Average alcohol use across the study period was the main exposure of interest. Past-year binge drinking and reduction in drinking from pre-baseline were additional exposures of interest. Within the context of low-level average drinking (averaging 11.7 g per day), higher average amount of alcohol consumed was associated with less atrophy in the left (B = 7.50, pFDR = 0.010) and right (B = 5.98, pFDR = 0.004) thalamus. Past-year binge-drinking was associated with poorer white matter integrity (B = -0.013, pFDR = 0.024). Consuming alcohol more heavily in the past was associated with greater atrophy in anterior (B = -12.73, pFDR = 0.048) and posterior (B = -17.88, pFDR = 0.004) callosal volumes over time. Across alcohol exposures and neuroimaging markers, no other relationships were statistically significant. Within the context of low-level drinking, very few relationships between alcohol use and brain macrostructure were identified. Meanwhile, heavier drinking was negatively associated with white matter integrity.

Indexed as

Alcohol DrinkingAtrophyBrainGray MatterMagnetic Resonance ImagingWhite MatterAgedAged, 80 and overAgingAmygdalaBinge DrinkingCorpus CallosumFemaleHippocampusHumansLongitudinal Studiesageingalcohol useepidemiologylongitudinal neuroimagingneurodegeneration

Identifiers

PMID38797559
PMCPMC11128337

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.