ArticleThe Journal of nutrition2024
A Large Proportion of the Neonatal Iron Pool Is Acquired from the Gestational Diet in a Murine Model.
Article in The Journal of nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundIron is crucial for growth and development, but excess iron is harmful. Neonatal mice have elevated concentrations of circulating iron, but the source of this iron is unclear. This lack of understanding makes it difficult to optimize early life iron balance.
objectivesIdentify the origins of neonatal tissue-specific iron pools using dietary manipulation and cross-fostering murine models.
methodsTo determine whether tissue-specific neonatal iron was primarily acquired during gestation or after birth, pups born to iron-sufficient or iron-deficient dams were cross-fostered, and tissues were harvested at postnatal days 3-5 to measure iron content. A separate set of female mice were fed a diet enriched with the stable iron isotope 57 (
resultsPerinatal iron deficiency resulted in smaller pups, and gestational iron deficiency resulted in lower neonatal serum and liver iron. Cross-fostering between dams with
conclusionsThis study provides quantitative values for the sources of neonatal iron, which may inform approaches to optimize neonatal iron status.
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