ArticleAllergy2024
Multi-omic integration reveals alterations in nasal mucosal biology that mediate air pollutant effects on allergic rhinitis.
Article in Allergy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Mucosal immunity and vaccine development.Signal transduction and targeted therapy · 2026Pooled it
- Risk factors for allergic rhinitis in preschool children: a meta-analysis and systematic review.BMC pediatrics · 2025Pooled it
- The epigenetic-immune-microbiome axis in early life: reprogramming the origins and endotypes of pediatric asthma.Frontiers in immunology · 2026Review
- The role of calcium homeostasis dysregulation in allergic rhinitis.Frontiers in immunology · 2026Review
- Calcitonin gene-related peptide as a neuroimmune amplifier in allergic rhinitis: from disease worsening to targeted drug intervention.Frontiers in immunology · 2026Review
- Integrative transcriptomic analysis identifies CCL22-associated immune signatures in air pollution-related atopic dermatitis.Frontiers in public health · 2026Article
- Airway transcriptome networks for ozone and PMGenome medicine · 2025Article
- The Prevalence of Allergic Rhinitis in Korean Children: Nationwide Surveys in the Periods 1995-2022.Allergy, asthma & immunology research · 2025Article
- Article
- Multiomic approaches for endotype discovery in allergy/immunology.The Journal of allergy and clinical immunology · 2025Article
- Chinese Expert Consensus on the Impact of Ambient Air Pollution on Allergic Rhinitis and Recommendations for Mitigation Strategies.Allergy, asthma & immunology research · 2025Review
- Screening and identification of key serum biomarkers between PM2.5 and-induced asthma onset.Frontiers in public health · 2025Article
- Elevated S100A8 in nasal mucosa correlates with epithelial barrier dysfunction in allergic rhinitis.Brazilian journal of otorhinolaryngologyArticle
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
backgroundAllergic rhinitis is a common inflammatory condition of the nasal mucosa that imposes a considerable health burden. Air pollution has been observed to increase the risk of developing allergic rhinitis. We addressed the hypotheses that early life exposure to air toxics is associated with developing allergic rhinitis, and that these effects are mediated by DNA methylation and gene expression in the nasal mucosa.
methodsIn a case-control cohort of 505 participants, we geocoded participants' early life exposure to air toxics using data from the US Environmental Protection Agency, assessed physician diagnosis of allergic rhinitis by questionnaire, and collected nasal brushings for whole-genome DNA methylation and transcriptome profiling. We then performed a series of analyses including differential expression, Mendelian randomization, and causal mediation analyses to characterize relationships between early life air toxics, nasal DNA methylation, nasal gene expression, and allergic rhinitis.
resultsAmong the 505 participants, 275 had allergic rhinitis. The mean age of the participants was 16.4 years (standard deviation = 9.5 years). Early life exposure to air toxics such as acrylic acid, phosphine, antimony compounds, and benzyl chloride was associated with developing allergic rhinitis. These air toxics exerted their effects by altering the nasal DNA methylation and nasal gene expression levels of genes involved in respiratory ciliary function, mast cell activation, pro-inflammatory TGF-β1 signaling, and the regulation of myeloid immune cell function.
conclusionsOur results expand the range of air pollutants implicated in allergic rhinitis and shed light on their underlying biological mechanisms in nasal mucosa.
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