Evidence map›Paper›PMID 38796702›Full record

ArticleMolecular therapy : the journal of the American Society of Gene Therapy2024

Evaluation of [

Bing Li, Palak Wadhwa, Walter Lerchner, Paolo Zanotti-Fregonara, Jeih-San Liow, Xuefeng Yan, Sami S Zoghbi, Sridhar Goud Nerella, Sanjay Telu, Cheryl L Morse and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy : the journal of the American Society of Gene Therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Bing LiLaboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20814, USA.
Palak WadhwaMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20814, USA.
Walter LerchnerLaboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20814, USA.
Paolo Zanotti-FregonaraMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20814, USA.
Jeih-San LiowMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20814, USA.
Xuefeng YanMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20814, USA.
Sami S ZoghbiMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20814, USA.
Sridhar Goud NerellaMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20814, USA.
Sanjay TeluMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20814, USA.
Cheryl L MorseMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20814, USA.
Oscar SolisBiobehavioral Imaging and Molecular Neuropsychopharmacology Unit, Neuroimaging Research Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA.
Juan L GomezBiobehavioral Imaging and Molecular Neuropsychopharmacology Unit, Neuroimaging Research Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA.
Daniel P HoltDepartment of Radiology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
Robert F DannalsDepartment of Radiology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
Alex C CumminsLaboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20814, USA.
Robert B InnisMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20814, USA.
Victor W PikeMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20814, USA.
Barry J RichmondLaboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20814, USA.
Michael MichaelidesBiobehavioral Imaging and Molecular Neuropsychopharmacology Unit, Neuroimaging Research Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA. Electronic address: mike.michaelides@nih.gov.
Mark A G EldridgeLaboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20814, USA. Electronic address: mark.eldridge@nih.gov.

Funding

PET Radiopharmaceutical SciencesZIAMH002793 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PIKE, VICTOR W · 2009 to 2025
$69.8M
Translational Evaluation Of PET RadiotracersZIAMH002795 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI INNIS, ROBERT · 2009 to 2025
$32.0M
Neural Mechanisms Of Motivation And RewardZIAMH002619 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI RICHMOND, BARRY J · 2009 to 2025
$21.3M
Neural Coding Of Visual StimuliZIAMH002032 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI RICHMOND, BARRY J · 2009 to 2025
$20.5M
Biobehavioral Imaging and Molecular Neuropsychopharmacology of Substance Abuse MechanismsZIADA000069 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI MICHAELIDES, MICHAEL · 2016 to 2025
$18.9M
Intramural NIH HHS ZIA DA000069Intramural NIH HHS ZIA MH002032Intramural NIH HHS ZIA MH002793Intramural NIH HHS ZIA MH002795
6 · The paper itself

Abstract

Positron emission tomography (PET) reporter systems are a valuable means of estimating the level of expression of a transgene in vivo. For example, the safety and efficacy of gene therapy approaches for the treatment of neurological and neuropsychiatric disorders could be enhanced via the monitoring of exogenous gene expression levels in the brain. The present study evaluated the ability of a newly developed PET reporter system [

Indexed as

BrainEstradiolGenes, ReporterMacaca mulattaPositron-Emission TomographyAnimalsFluorine RadioisotopesGene ExpressionGenetic VectorsHumansLentivirusReceptors, EstrogenRNA, Small InterferingEstradiolFluorine-18Fluorine RadioisotopesReceptors, EstrogenRNA, Small Interfering[18F]fluoroestradiolChRERαgene expressionPET reporterrhesus monkey

Identifiers

PMID38796702
PMCPMC11286805

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.