Evidence map›Paper›PMID 38796679›Full record

ArticleRheumatology (Oxford, England)2025

Extracorporeal membrane oxygenation for acute lung injury in idiopathic inflammatory myopathies-a potential lifesaving intervention.

Boyang Zheng, Ellen Eline, Lillian Xu, Kun Huang, Greet Hermans, Michael Perch, Gordan Samoukovic, Ellen De Langhe, Maryam Dastmalchi, Lisa Christopher-Stine and 2 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Rheumatology (Oxford, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Boyang ZhengDivision of Rheumatology, University of British Columbia, Vancouver, Canada.
Ellen ElineDivision of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Lillian XuDivision of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Kun HuangDivision of Rheumatology, University of British Columbia, Vancouver, Canada.
Greet HermansMedical Intensive Care Unit, University Hospitals Leuven, Leuven, Belgium.ORCID 0000-0001-5340-1500
Michael PerchDivision of Lung Transplantation, Heart Center, Rigshospitalet, Copenhagen, Denmark.ORCID 0000-0001-9740-1246
Gordan SamoukovicDivision of Rheumatology, McGill University Health Centre, Montreal, Canada.
Ellen De LangheDivision of Rheumatology, University Hospitals Leuven, Leuven, Belgium.ORCID 0000-0002-4045-2146
Maryam DastmalchiDivision of Rheumatology, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
Lisa Christopher-StineDivision of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-7150-7306
Louise Pyndt DiederichsenDepartment of Rheumatology, Odense University Hospital, Odense, Denmark.ORCID 0000-0002-2581-8912
Valérie LeclairDivision of Rheumatology, Jewish General Hospital, Montreal, Canada.ORCID 0000-0001-8643-6697

Funding

Medical Scientist Training ProgramT32GM136577 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI ANDREA L COX · 2020 to 2026
$13.4M
NIGMS NIH HHS T32 GM136577
6 · The paper itself

Abstract

objectivesIdiopathic inflammatory myopathies (IIM) can present with acute IIM-related lung injury and respiratory failure, leading to a high mortality risk in intensive care units (ICU). Extracorporeal membrane oxygenation (ECMO) in acute respiratory distress syndrome can be lifesaving. We aimed to report a case series of IIM patients that received ECMO.

methodsPatients with IIM from tertiary care centres in Belgium, Canada, Denmark, USA and Sweden who underwent ECMO were reviewed to describe clinical characteristics, disease outcomes and hospitalization course. Clinical characteristics at admission and during ICU stay including ECMO complications and mortality causes were summarized.

resultsThe study included 22 patients (50% female, mean ± SD age at admission 47 ± 12 years) with anti-MDA5 positive dermatomyositis (68%), anti-synthetase syndrome (14%), polymyositis (9%), overlap myositis (5%) and non-MDA5 dermatomyositis (5%). Patients had low comorbidity scores and 46% had received immunosuppression before their ICU admission. Eight (36%) patients died in the ICU, six (27%) were bridged to recovery and eight (36%) were bridged to transplant. When comparing patients bridged to recovery and those who died in the ICU, those who died were older (P = 0.03) and had higher median Charlson comorbidity index scores (P = 0.05). Both groups had similar frequencies of ECMO-related complications (33% vs 50%, P = 0.94).

conclusionIn the patients exposed to ECMO in this case series, 14 were successfully bridged to recovery or transplant, while 8 died in the ICU. Large studies are needed to collect data on clinical outcomes in patients with IIM-ILD exposed to ECMO to identify the best candidates for the intervention.

Indexed as

Acute Lung InjuryExtracorporeal Membrane OxygenationMyositisRespiratory Distress SyndromeAdultFemaleHumansIntensive Care UnitsMaleMiddle AgedRetrospective StudiesTreatment Outcomeanti-MDA5 antibodydermatomyositisextracorporeal membrane oxygenationlung transplantationrapid progressive interstitial lung disease

Identifiers

PMID38796679
PMCPMC11962946

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.