Evidence map›Paper›PMID 38796656›Full record

ArticleMolecular biology reports2024

Expression of CD44 is associated with aggressiveness in seminomas.

Vasiliki T Labropoulou, Dimitra Manou, Panagiota Ravazoula, Fatimah Mohammed Alzahrani, Haralabos P Kalofonos, Achilleas D Theocharis

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In one paragraph

Article in Molecular biology reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Vasiliki T LabropoulouDepartment of Internal Medicine, Division of Hematology, University of Patras Medical School, Patras, Greece. vaslabrop@upatras.gr.
Dimitra ManouBiochemistry, Biochemical Analysis and Matrix Pathobiology Research Group, Laboratory of Biochemistry, Department of Chemistry, University of Patras, Patras, Greece.
Panagiota RavazoulaDepartment of Pathology, University Hospital of Patras, Patras, 26504, Greece.
Fatimah Mohammed AlzahraniDepartment of Chemistry, College of Science, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh, 11671, Saudi Arabia.
Haralabos P KalofonosClinical Oncology Laboratory, Division of Oncology, Department of Medicine, University of Patras, Rio, 26504, Greece.
Achilleas D TheocharisBiochemistry, Biochemical Analysis and Matrix Pathobiology Research Group, Laboratory of Biochemistry, Department of Chemistry, University of Patras, Patras, Greece. atheoch@upatras.gr.

Funding

Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia PNURSP-HC2022/6
6 · The paper itself

Abstract

backgroundTesticular germ cell tumors (TGCTs) exhibit diverse biological and pathological features and are divided in two main types, seminomas and nonseminomatous germ cell tumors (NSGCTs). CD44 is a cell surface receptor, which is highly expressed in malignancies and is implicated in tumorigenesis affecting cell-matrix interactions and cell signaling. METHODS AND

resultsHere, we examined the expression of CD44 in tumor cell lines and in patients' material. We found that CD44 is over-expressed in TGCTs compared to normal tissues. Immunohistochemical staining in 71 tissue specimens demonstrated increased expression of CD44 in some patients, whereas CD44 was absent in normal tissue. In seminomas, a high percentage of tumor and stromal cells showed cytoplasmic and/or cell surface staining for CD44 as well as increased staining for CD44 in the tumor stroma was found in some cases. The increased expression of CD44 either in tumor cells or in stromal components was associated with tumor size, nodal metastasis, vascular/lymphatic invasion, and disease stage only in seminomas. The increased stromal expression of CD44 in TGCTs was positively associated with angiogenesis.

conclusionsCD44 may exhibit diverse biological functions in seminomas and NSGCTs. The expression of CD44 in tumor cells as well as in tumor stroma fosters an aggressive phenotype in seminomas and should be considered in disease treatment.

Indexed as

Hyaluronan ReceptorsSeminomaTesticular NeoplasmsAdultBiomarkers, TumorCell Line, TumorGene Expression Regulation, NeoplasticHumansImmunohistochemistryMaleMiddle AgedNeoplasms, Germ Cell and EmbryonalBiomarkers, TumorCD44 protein, humanHyaluronan ReceptorsCD44Extracellular matrixHyaluronan receptorSeminomaTesticular germ cell tumorsTumor microenvironment

Identifiers

PMID38796656
PMCPMC11127849

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