Evidence map›Paper›PMID 38796539›Full record

ArticleNPJ vaccines2024

Sustained antigen delivery improves germinal center reaction and increases antibody responses in neonatal mice.

Leda Lotspeich-Cole, Swetha Parvathaneni, Jiro Sakai, Lunhua Liu, Kazuyo Takeda, Robert C Lee, Mustafa Akkoyunlu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ vaccines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Leda Lotspeich-ColeUS FDA/CBER/OVRR/DBPAP, 10903 New Hampshire Avenue, Silver Spring, MD, USA.ORCID http://orcid.org/0000-0002-3724-7547
Swetha ParvathaneniUS FDA/CBER/OVRR/DBPAP, 10903 New Hampshire Avenue, Silver Spring, MD, USA.
Jiro SakaiUS FDA/CBER/OVRR/DBPAP, 10903 New Hampshire Avenue, Silver Spring, MD, USA.
Lunhua LiuUS FDA/CBER/OVRR/DBPAP, 10903 New Hampshire Avenue, Silver Spring, MD, USA.
Kazuyo TakedaUS FDA/CBER/OBRR/DBCD, 10903 New Hampshire Avenue, Silver Spring, MD, USA.
Robert C LeeUS FDA/CBER/OVRR/DBPAP, 10903 New Hampshire Avenue, Silver Spring, MD, USA.
Mustafa AkkoyunluUS FDA/CBER/OVRR/DBPAP, 10903 New Hampshire Avenue, Silver Spring, MD, USA. Mustafa.Akkoyunlu@fda.hhs.gov.ORCID http://orcid.org/0000-0001-9958-4031

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neonates and young infants are known to have limited responses to pediatric vaccines due to reduced germinal center formation. Extended vaccine antigen dosing was previously shown to expand germinal center formation and improve humoral responses in adult mice. We report that sustained antigen delivery through sequential dosing overcomes neonatal limitations to form germinal center reactions and improves humoral immunity. Thus, vaccine strategies that extend the release of vaccine antigens may reduce the number of doses, and time needed, to achieve protective immunity in neonates and young infants.

Identifiers

PMID38796539
PMCPMC11128021

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.