Evidence map›Paper›PMID 38796521›Full record

ArticleScientific reports2024

Deep-learning segmentation to select liver parenchyma for categorizing hepatic steatosis on multinational chest CT.

Zhongyi Zhang, Guixia Li, Ziqiang Wang, Feng Xia, Ning Zhao, Huibin Nie, Zezhong Ye, Joshua S Lin, Yiyi Hui, Xiangchun Liu

Abstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. [Research progress and future prospects for artificial intelligence in the diagnosis and treatment of fatty liver disease].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zhongyi ZhangDepartment of Nephrology, Multidisciplinary Innovation Center for Nephrology, The Second Hospital of Shandong University, Shandong University, Jinan, 250033, Shandong, China.
Guixia LiDepartment of Nephrology, Shenzhen Third People's Hospital, the Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, 518112, Guangdong, China.
Ziqiang WangDepartment of Nephrology, The First Affiliated Hospital of Hainan Medical University, Haikou, 570102, Hainan, China.
Feng XiaDepartment of Cardiovascular Surgery, Wuhan Asia General Hospital, Wuhan, 430000, Hubei, China.
Ning ZhaoThe First Clinical Medical School, Shanxi Medical University, Taiyuan, 030001, Shanxi, China.
Huibin NieDepartment of Nephrology, Chengdu First People's Hospital, Chengdu, 610021, Sichuan, China.
Zezhong YeIndependent Researcher, Boston, MA, 02115, USA.
Joshua S LinKeck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.
Yiyi Hui *Department of Medical Imaging, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China. huiyiyi@sdfmu.edu.cn.
Xiangchun Liu *Department of Nephrology, Multidisciplinary Innovation Center for Nephrology, The Second Hospital of Shandong University, Shandong University, Jinan, 250033, Shandong, China. liuxiangchun@sdu.edu.cn.

Funding

Foundation of Shenzhen Third People's Hospital G2022030Hainan Provincial Natural Science Foundation of China 821QN406The Second Hospital of Shandong University 2022YP46
6 · The paper itself

Abstract

Unenhanced CT scans exhibit high specificity in detecting moderate-to-severe hepatic steatosis. Even though many CTs are scanned from health screening and various diagnostic contexts, their potential for hepatic steatosis detection has largely remained unexplored. The accuracy of previous methodologies has been limited by the inclusion of non-parenchymal liver regions. To overcome this limitation, we present a novel deep-learning (DL) based method tailored for the automatic selection of parenchymal portions in CT images. This innovative method automatically delineates circular regions for effectively detecting hepatic steatosis. We use 1,014 multinational CT images to develop a DL model for segmenting liver and selecting the parenchymal regions. The results demonstrate outstanding performance in both tasks. By excluding non-parenchymal portions, our DL-based method surpasses previous limitations, achieving radiologist-level accuracy in liver attenuation measurements and hepatic steatosis detection. To ensure the reproducibility, we have openly shared 1014 annotated CT images and the DL system codes. Our novel research contributes to the refinement the automated detection methodologies of hepatic steatosis on CT images, enhancing the accuracy and efficiency of healthcare screening processes.

Indexed as

Deep LearningFatty LiverLiverTomography, X-Ray ComputedFemaleHumansMaleReproducibility of ResultsComputed tomography, nnU-Net, Deep learning, Hepatic steatosis

Identifiers

PMID38796521
PMCPMC11127985

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.