Evidence map›Paper›PMID 38796500›Full record

ArticlePilot and feasibility studies2024

Pre-operative mechanical bowel preparation and prophylactic oral antibiotics for pediatric patients undergoing elective colorectal surgery: a protocol for a randomized controlled feasibility trial.

Daniel Briatico, Helene Flageole, Noora Al-Shahwani, Forough Farrokhyar, Lisa VanHouwelingen

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pilot and feasibility studies, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03593252 (Pre-Operative Mechanical Bowel Preparation And Prophylactic Oral Antibiotics For Pediatric Patients Undergoing Elective Colorectal Surgery), which is not on this map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03593252 naunknown statusnot on this map

Pre-Operative Mechanical Bowel Preparation And Prophylactic Oral Antibiotics For Pediatric Patients Undergoing Elective Colorectal Surgery: A Feasibility Randomized Controlled Trial

TypeinterventionalSponsorMcMaster UniversityRan2022 to 2024Enrolled81ConditionsColostomy, Hirschsprung Disease - Pull Through, Necrotizing Enterocolitis, Inflammatory Bowel DiseasesArmsSenna, Sodium Picosulfate, Magnesium Oxide and Citric Acid, Metronidazole Oral, Neomycin, Cefazolin
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Daniel BriaticoMcMaster Pediatric Surgery Research Collaborative, McMaster University, Hamilton, ON, Canada.
Helene FlageoleMcMaster Pediatric Surgery Research Collaborative, McMaster University, Hamilton, ON, Canada.
Noora Al-ShahwaniMcMaster Pediatric Surgery Research Collaborative, McMaster University, Hamilton, ON, Canada.
Forough FarrokhyarDepartment of Health Research Methods, Evidence & Impact, Department of Surgery, McMaster University, Hamilton, ON, Canada.
Lisa VanHouwelingenMcMaster Pediatric Surgery Research Collaborative, McMaster University, Hamilton, ON, Canada. vanhoul@mcmaster.ca.ORCID http://orcid.org/0000-0003-0156-0731

Funding

Hamilton Health Sciences 131159543-RR0001Hamilton Health Sciences NIF-21513
6 · The paper itself

Abstract

backgroundInfections after elective colorectal surgery remain a significant burden for patients and the healthcare system. Adult studies suggest that the combination of oral antibiotics and mechanical bowel preparation is effective at reducing infections after colorectal surgery. In children, there is limited evidence for either of these practices and the utility of combining oral antibiotics with mechanical bowel preparation remains uncertain.

methodsThis study aims to determine the feasibility of conducting a randomized controlled trial assessing the efficacy of oral antibiotics, with or without mechanical bowel preparation, in reducing the rates of post-operative infection in pediatric colorectal surgery. Participants aged 3 months to 18 years undergoing elective colorectal surgery will be randomized pre-operatively to one of three trial arms: (1) oral antibiotics; (2) oral antibiotics and mechanical bowel preparation; or (3) standard care. Twelve patients will be included in each trial arm. Feasibility outcomes of interest include the rate of participant recruitment, post-randomization exclusions, protocol deviations, adverse events, and missed follow-up appointments. Secondary outcomes include the rate of post-operative surgical site infections, length of hospital stay, time to full enteral feeds, reoperation, readmission, and complications. DISCUSSION: If the results of this trial prove feasible, a multi-center trial will be completed with sufficient power to evaluate the optimal pre-operative bowel preperation for pediatric patients undergoing elective colorectal surgery.

trial registrationClinicalTrials.gov: NCT03593252.

Indexed as

AntibioticsColorectal surgeryMechanical bowel preparationPediatricSurgical site infection

Identifiers

PMID38796500
PMCPMC11127310

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.